EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.305 | S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C |
- |
Streptomyces olivaceus |
S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C |
- |
? |
2.1.1.305 | S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C |
the enzyme is involved in the biosynthesis of the polyketide elloramycin |
Streptomyces olivaceus |
S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C |
- |
? |
2.1.1.305 | S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C |
using as biotransformation host strain EPM1 (expressing elmMI) about 24% of the precursor 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C is converted into 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C. No activity with substrates lacking the hydroxy group at C-2' (8-demethyl-8-alpha-L-oleandrosyl tetracenomycin C or 8-demethyl-8-alpha-L-olivosyl tetracenomycin C) |
Streptomyces olivaceus |
S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C |
- |
? |
2.1.1.305 | S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C |
- |
Streptomyces olivaceus Tü2353 |
S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C |
- |
? |
2.1.1.305 | S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C |
the enzyme is involved in the biosynthesis of the polyketide elloramycin |
Streptomyces olivaceus Tü2353 |
S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C |
- |
? |
2.1.1.305 | S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C |
using as biotransformation host strain EPM1 (expressing elmMI) about 24% of the precursor 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C is converted into 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C. No activity with substrates lacking the hydroxy group at C-2' (8-demethyl-8-alpha-L-oleandrosyl tetracenomycin C or 8-demethyl-8-alpha-L-olivosyl tetracenomycin C) |
Streptomyces olivaceus Tü2353 |
S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C |
- |
? |