EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.303 | more |
NcsB1 also recognizes other dihydroxynaphthoic acids as substrates and catalyzes regiospecific O-methylation. The carboxylate and its ortho-hydroxy groups of the substrate appear to be crucial for NcsB1 substrate recognition and binding, and O-methylation takes place only at the free hydroxy group of these dihydroxynaphthoic acids |
Streptomyces carzinostaticus |
? |
- |
? |
2.1.1.303 | S-adenosyl-L-methionine + 1,4-dihydroxy-2-naphthoic acid |
kcat/KM is 10% compared to the wild-type value |
Streptomyces carzinostaticus |
S-adenosyl-L-homocysteine + 1-hydroxy-4-methoxy-2-naphthoate |
- |
? |
2.1.1.303 | S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate |
- |
Streptomyces carzinostaticus |
S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate |
- |
? |
2.1.1.303 | S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate |
the enzyme is involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin |
Streptomyces carzinostaticus |
S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate |
- |
? |
2.1.1.303 | S-adenosyl-L-methionine + 3,5-dihydroxy-2-naphthoate |
kcat/KM is 23% compared to the wild-type value |
Streptomyces carzinostaticus |
S-adenosyl-L-homocysteine + 3-hydroxy-5-methoxy-2-naphthoate |
- |
? |
2.1.1.303 | S-adenosyl-L-methionine + 3,7-dihydroxy-2-naphthoate |
kcat/KM is 14% compared to the wild-type value |
Streptomyces carzinostaticus |
S-adenosyl-L-homocysteine + 3-hydroxy-7-methoxy-2-naphthoate |
- |
? |