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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.1.1.25more 3-methoxy- and 3,5-dimethoxy-substituted 4-hydroxy-benzaldehydes, -benzoic acids, and -acetophenones are the preferred substrates. The corresponding 3,4-dihydroxy compounds are methylated relatively slowly, while the 3-hydroxy-4-methoxy compounds are almost inactive as substrates. Substituents in both the 2 and 4 positions relative to the hydroxyl group appear to be essential for significant enzyme attack of a substrate. Xenobiotic compounds such as 2,4-dichlorophenol and 2,4-dibromophenol are methylated almost as readily as 4-hydroxy-3-methoxyacetophenone. No substrates: homovanillic acid, caffeic acid, ferulic acid Phanerodontia chrysosporium ? - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + 2,4-dibromophenol - Phanerodontia chrysosporium S-adenosyl-L-homocysteine + 2,4-dibromo-1-methoxybenzene - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + 2,4-dichlorophenol - Phanerodontia chrysosporium S-adenosyl-L-homocysteine + 2,4-dichloro-1-methoxybenzene - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxyacetophenone - Phanerodontia chrysosporium S-adenosyl-L-homocysteine + 3,4,5-trimethoxyacetophenone - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxybenzaldehyde - Phanerodontia chrysosporium S-adenosyl-L-homocysteine + 3,4,5-trimethoxybenzaldehyde - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxybenzoic acid - Phanerodontia chrysosporium S-adenosyl-L-homocysteine + 3,4,5-trimethoxybenzoic acid - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + 4-hydroxy-3-methoxyacetophenone - Phanerodontia chrysosporium S-adenosyl-L-homocysteine + 3,4-dimethoxyacetophenone - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + 4-hydroxy-3-methoxybenzaldehyde - Phanerodontia chrysosporium S-adenosyl-L-homocysteine + 3,4-dimethoxybenzaldehyde - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + 4-hydroxy-3-methoxybenzoic acid - Phanerodontia chrysosporium S-adenosyl-L-homocysteine + 3,4-dimethoxybenzoic acid - ?
Display the reaction diagram Show all sequences 2.1.1.25S-adenosyl-L-methionine + acetaminophen - Homo sapiens S-adenosyl-L-homocysteine + N-(4-methoxyphenyl)-acetamide - ?
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