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EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
2.1.1.191	S-adenosyl-L-methionine + cytosine1962 in 23S rRNA	-	Escherichia coli K-12	S-adenosyl-L-homocysteine + 5-methylcytosine1962 in 23S rRNA	-	?
2.1.1.191	S-adenosyl-L-methionine + cytosine1962 in 23S rRNA	the enzyme can methylate naked 23S rRNA, but not assembled 50S ribosomal subunits or 70S ribosomes	Escherichia coli	S-adenosyl-L-homocysteine + 5-methylcytosine1962 in 23S rRNA	-	?
2.1.1.191	S-adenosyl-L-methionine + cytosine1962 in 23S rRNA	the enzyme specifically modifies Escherichia coli 23S rRNA at nucleotide C1962 to form 5-methylcytosine	Escherichia coli	S-adenosyl-L-homocysteine + 5-methylcytosine1962 in 23S rRNA	-	?

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Release 2023.1 (January 2023)