EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.168 | S-adenosyl-L-methionine + uridine2791 in 21S rRNA |
mitochondria of the yeast Saccharomyces cerevisiae assemble their ribosomes from ribosomal proteins, encoded by the nuclear genome (with one exception), and rRNAs of 15S and 21S, encoded by the mitochondrial genome. Unlike cytoplasmic rRNA, which is highly modified, mitochondrial rRNA contains only three modified nucleotides: a pseudouridine and two 2'-O-methylated riboses (Gm2270 and Um2791) located at the peptidyl transferase centre of 21S rRNA. Mrm2 is required for methylating U2791 of 21S rRNA |
Saccharomyces cerevisiae |
S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA |
- |
? |
2.1.1.168 | S-adenosyl-L-methionine + uridine2791 in 21S rRNA |
Mrm2p methylates the 21S rRNA at position U2791 in vitro, when it is assembled with proteins into the ribosomal large subunit ir the precursor of the ribosomal large subunit. NO methylation is observed with deproteinized rRNA |
Saccharomyces cerevisiae |
S-adenosyl-L-homocysteine + 2'-O-methyluridine2791 in 21S rRNA |
- |
? |