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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
2.1.1.132
Adenosyl-L-methionine + precorrin-6Y
-
Pseudomonas denitrificans (nom. rej.)
Adenosyl-L-homocysteine + precorrin-8X + CO2
-
?
2.1.1.132
Adenosyl-L-methionine + precorrin-6Y
-
Pseudomonas denitrificans (nom. rej.) SC510 Rif
Adenosyl-L-homocysteine + precorrin-8X + CO2
-
?
2.1.1.132
Adenosyl-L-methionine + precorrin-6Y
enzyme of the vitamin B12 biosynthetic pathway
Pseudomonas denitrificans (nom. rej.)
?
-
?
2.1.1.132
Adenosyl-L-methionine + precorrin-6Y
enzyme of the cobalamin biosynthetic pathway
Salmonella enterica subsp. enterica serovar Typhimurium
?
-
?
2.1.1.132
Adenosyl-L-methionine + precorrin-6Y
enzyme of the cobalamin biosynthetic pathway
Pseudomonas denitrificans (nom. rej.)
?
-
?
2.1.1.132
more
evolutionary origin of the cbiT
Methanothermobacter thermautotrophicus
?
-
?
2.1.1.132
more
the organism performs the aerobic cobalamin biosynthesis variant
Pseudomonas denitrificans (nom. rej.)
?
-
?
2.1.1.132
more
the organism performs the anaerobic cobalamin biosynthesis variant, the gene cbiE of Propionibacterium freudenreichii is organized in a single ORF with genes cbiH and cbiG, overview
Propionibacterium freudenreichii
?
-
?
2.1.1.132
more
S-adenosyl-L-methionine binding structure and mechanism of CbiT
Methanothermobacter thermautotrophicus
?
-
?
2.1.1.132
S-adenosyl-L-methionine + cobalt-precorrin-6Y + 6 H+
methylation and decarboxylation are catalyzed by 2 different enzymes in Propionibacterium freudenreichii, encoded by gene cbiE, organized in a orf/single gene with cbiG and cbiH, which is responsible for the methylations at C5 and C15, and by gene cbiT, which is responsible for the decarboxylation, steps of the anaerobic cobalamin biosynthesis, pathway overview
Propionibacterium freudenreichii
S-adenosyl-L-homocysteine + cobalt-precorrin-8X + 2 H2O
-
?
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