EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.1.1.100 | more |
overexpression of the enzyme may protect against endothelial cell apoptosis by enhancing, the carboxyl methylation posttranslational modification, activity, and subsequent intracellular signalling pathway of Ras GTPase |
Bos taurus |
? |
- |
? |
| 2.1.1.100 | more |
the enzyme regulates Rac1 activity by controlling the interaction of Rac1 activity by controlling the interaction of Rac1 with Rho guanine nucleotide dissociation inhibitor, the enzyme regulates membrane accumulation and GTP loading of Rac1 |
Homo sapiens |
? |
- |
? |
| 2.1.1.100 | more |
inhibition of Icmt significantly decreases the activation of both RhoA and Rac1 involving Rho GDP-dissociation inhibitor, RhoGDI, overview. Icmt inhibition impairs RhoGTPase activation |
Homo sapiens |
? |
- |
? |
| 2.1.1.100 | more |
the ICMT isozyme catalyzes the methylation of C-terminal isoprenylcysteines |
Arabidopsis thaliana |
? |
- |
? |
| 2.1.1.100 | more |
isoprenylcysteine carboxyl methyltransferase methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins |
Pseudoceratina sp. |
? |
- |
? |
| 2.1.1.100 | more |
isozyme substrate specificity, no activity with N-acetyl-S-trans-geranyl-L-cysteine, overview |
Arabidopsis thaliana |
? |
- |
? |
| 2.1.1.100 | more |
isoprenylcysteine carboxyl methyltransferase methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins |
Pseudoceratina sp. 1247 |
? |
- |
? |
| 2.1.1.100 | S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine |
- |
Bos taurus |
S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester |
- |
? |
| 2.1.1.100 | S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine |
the enzyme modulates endothelial monolayer per meability by altering RhoA carboxyl methylation and activation, thus changing the organization of intercellular junctions. Carboxy methylation of RhoA may modulate endothelial barrier function |
Bos taurus |
S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester |
- |
? |
| 2.1.1.100 | S-adenosyl-L-methionine + 4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
- |
? |
