EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.1 | L-methionine + nicotinamide |
- |
Rattus norvegicus |
L-homocysteine + 1-methylnicotinamide |
- |
? |
2.1.1.1 | more |
enzyme may function in detoxificating of numerous alkaloids |
Sus scrofa |
? |
- |
? |
2.1.1.1 | more |
NNMT catalyzes the N-methylation of nicotinamide and other structural analogs, and is involved in the biotransformation of many drugs and xenobiotic compounds |
Homo sapiens |
? |
- |
? |
2.1.1.1 | more |
development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview |
Mus musculus |
? |
- |
? |
2.1.1.1 | more |
development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview |
Homo sapiens |
? |
- |
? |
2.1.1.1 | more |
development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview |
Oryctolagus cuniculus |
? |
- |
? |
2.1.1.1 | more |
NNMT uses a rapid equilibrium ordered mechanism, where NNMT first binds S-adenosyl-L-methionine, which is followed by nicotinamide. Methyl transfer occurs, and methylated nicotinamide and S-adenosylhomocysteine are released consecutively |
Homo sapiens |
? |
- |
- |
2.1.1.1 | nicotinamide + S-adenosyl-L-methionine |
- |
Homo sapiens |
1-methylnicotinamide + S-adenosyl-L-homocysteine |
- |
? |
2.1.1.1 | S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinoline |
- |
Sus scrofa |
S-adenosyl-L-homocysteine + ? |
- |
? |
2.1.1.1 | S-adenosyl-L-methionine + 2-methoxypyridine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + 1-methyl-2-methoxypyridinium |
- |
? |