EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.20.4.3 | arseno-mycothiol + mycoredoxin |
- |
Corynebacterium glutamicum |
arsenite + mycothiol-mycoredoxin disulfide |
a second mycothiol recycles mycoredoxin and forms mycothione |
? |
| 1.20.4.3 | arseno-mycothiol + mycoredoxin |
reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. The substrate arseno-mycothiol is formed by arsenate-mycothiol transferase. A second mycothiol recycles mycoredoxin and forms mycothione |
Corynebacterium glutamicum |
arsenite + mycothiol-mycoredoxin disulfide |
- |
? |
| 1.20.4.3 | insulin + dithiothreitol |
- |
Corynebacterium pseudotuberculosis |
? |
- |
? |
| 1.20.4.3 | more |
isoform mycoredoxin-1 acts as an oxidoreductase exclusively linked to the mycothiol electron transfer pathway and can reduce S-mycothiolated mixed disulfides. Mycoredoxin-1 has a redox potential of -218 mV and hydrogen bonding with neighbouring residues lowers the pKa of its N-terminal nucleophilic cysteine |
Mycolicibacterium smegmatis |
? |
- |
? |
| 1.20.4.3 | more |
the enzyme directly reduces the oxidized form of alkyl hydroxyperoxide reductase E, through a protein mixed disulfide with the N-terminal cysteine of mycoredoxin-1 and the sulfenic acid derivative of the peroxidatic cysteine of alkyl hydroxyperoxide reductase E |
Mycobacterium tuberculosis |
? |
- |
? |
| 1.20.4.3 | more |
the enzyme receives electrons through the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-disulfide mechanism. The enzyme uses a monothiol-disulfide exchange mechanism to reduce S-mycothiolated mixed disulfides and intramolecular disulfides. The enzyme has no oxidase properties |
Mycobacterium tuberculosis |
? |
- |
? |
| 1.20.4.3 | more |
the enzyme reduces the sulfenic acid intermediate via the formation of an S-mycothiolated methionine sulfoxide reductase A intermediate which is then recycled by mycoredoxin and the second molecule of mycothiol |
Corynebacterium glutamicum |
? |
- |
? |
| 1.20.4.3 | more |
the enzyme serve as reducing power for mycothiol peroxidase |
Corynebacterium glutamicum |
? |
- |
? |
| 1.20.4.3 | more |
the enzyme receives electrons through the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-disulfide mechanism. The enzyme uses a monothiol-disulfide exchange mechanism to reduce S-mycothiolated mixed disulfides and intramolecular disulfides. The enzyme has no oxidase properties |
Mycobacterium tuberculosis H37Rv |
? |
- |
? |
