EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    1.18.1.6 | 2 ferricyanide + NADPH |
diaphorase activity |
Mycobacterium tuberculosis |
2 ferrocyanide + NADP+ + H+ |
- |
? |
| 1.18.1.6 | 2 ferricyanide + NADPH |
the enzyme also has NADPH-ferricyanide activity |
Bos taurus |
2 ferrocyanide + NADP+ + H+ |
- |
? |
| 1.18.1.6 | ferricyanide + NADH |
- |
Mycobacterium tuberculosis |
ferrocyanide + NAD+ + H+ |
- |
r |
| 1.18.1.6 | more |
the enzyme contains a second, kinetically distinct and inhibitory pyridine nucleotide-binding site |
Mycobacterium tuberculosis |
? |
- |
? |
| 1.18.1.6 | more |
adrenodoxin stimulates the oxidation of NADPH by 1,4-benzoquinone, catalyzed by NADPH:adrenodoxin reductase. It prevents the enzyme inhibition by NADPH and forms an additional pathway of benzoquinone reduction presumably via reduced adrenodoxin. Adrenodoxin decreases the affinity of the enzyme for NADPH by a limiting factor of 3 and NADP+ decreases the enzyme affinity for adrenodoxin |
Bos taurus |
? |
- |
? |
| 1.18.1.6 | more |
anaerobic reduction of AdR with NADPH or the photoreduction of AdR in the presence of NADP+ and EDTA produces a multicomponent equilibrium which is dependent upon the concentration of NADPH and the temperature |
Bos taurus |
? |
- |
? |
| 1.18.1.6 | more |
modified adrenodoxin (at His-10, His-66, and His-62 with diethyl dicarbonate) exhibits reduced affinity for adrenodoxin reductase |
Bos taurus |
? |
- |
? |
| 1.18.1.6 | more |
NADP+ is also oxidized to 3-carboxamide-4-pyridone adenine dinucleotide phosphate by adrenodoxin reductase in the presence of air oxygen |
Bos taurus |
? |
- |
? |
| 1.18.1.6 | NADPH + H+ + oxidized 2,6-dichlorophenolindophenol |
diaphorase activity |
Mycobacterium tuberculosis |
NADP+ + reduced 2,6-dichlorophenolindophenol |
- |
? |
| 1.18.1.6 | NADPH + oxidized ferredoxin |
- |
Sus scrofa |
NADP+ + reduced ferredoxin |
- |
? |
