EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.14.99.66 | a [histone H3]-N6,N6-dimethyl-L-lysine4 + ferricenium + H2O |
- |
Homo sapiens |
a [histone H3]-N6-methyl-L-lysine4 + formaldehyde + ferrocene |
- |
? |
| 1.14.99.66 | a [histone H3]-N6,N6-dimethyl-L-lysine4 + O2 + 2 H2O |
- |
Homo sapiens |
a [histone H3]-L-lysine4 + 2 formaldehyde + 2 H2O2 |
- |
? |
| 1.14.99.66 | a [histone H3]-N6-methyl-L-lysine4 + acceptor + H2O |
- |
Homo sapiens |
a [histone H3]-L-lysine4 + formaldehyde + reduced acceptor |
- |
? |
| 1.14.99.66 | dimethylated histone 3-Lys4 peptide + H2O |
the enzyme specifically removes methyl groups from Lys4 of histone 3. The enzyme exhibits oxidase activity (with production of H2O2) but it can function also with a synthetic mono-electronic acceptor |
Homo sapiens |
? |
- |
? |
| 1.14.99.66 | H3(1-20) K4-dimethylated peptide + 2-oxoglutarate + O2 |
- |
Homo sapiens |
H3(1-20) K4-monomethylated peptide + succinate + formaldehyde + CO2 |
- |
? |
| 1.14.99.66 | H3K4me2 (1-21 aa) peptide + 2-oxoglutarate + O2 |
- |
Homo sapiens |
H3K4me1 (1-21 aa) peptide + succinate + formaldehyde + CO2 |
- |
? |
| 1.14.99.66 | H3K4me2 (1-21 aa) peptide + 2-oxoglutarate + O2 |
a peptide corresponding to the first 21 amino acids of histone H3 with a dimethylated lysine at the fourth residue [ARTK(diMe)QTARKSTGGKAPRKQLA] |
Homo sapiens |
H3K4me1 (1-21 aa) peptide + succinate + formaldehyde + CO2 |
- |
? |
| 1.14.99.66 | H3K4me2 1-21 peptide + 2-oxoglutarate + O2 |
- |
Homo sapiens |
H3K4me1 1-21 peptide + succinate + formaldehyde + CO2 |
- |
? |
| 1.14.99.66 | H3K4me2 peptide 3-21 + 2-oxoglutarate + O2 |
- |
Homo sapiens |
H3K4me1 peptide 3-21 + succinate + formaldehyde + CO2 |
- |
? |
| 1.14.99.66 | histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 |
- |
Mus musculus |
histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 |
- |
? |
