EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
- |
Mycobacterium avium |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
- |
Mycolicibacterium smegmatis |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
- |
Mycolicibacterium thermoresistibile |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
- |
Chloracidobacterium thermophilum |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
the enzyme is part of the biosynthesis pathway of ergothioneine |
Mycolicibacterium smegmatis |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
hercynine i.e. Nalpha,Nalpha,Nalpha-trimethyl-L-histidine. The enzyme is specific for both hercynine and gamma-L-glutamyl-L-cysteine. No activity with cysteine, N-acetylcysteine, or glutathione |
Mycolicibacterium smegmatis |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
i.e. N-alpha-trimethyl histidine |
Mycolicibacterium thermoresistibile |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
the enzyme is extremely specific in terms of substrate specificity |
Mycolicibacterium smegmatis |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
i.e. N-alpha-trimethyl histidine. Substrate binding mode, detailed overview |
Mycolicibacterium thermoresistibile |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |
1.14.99.50 | hercynine + gamma-L-glutamyl-L-cysteine + O2 |
sulfoxide incorporation at C2 by EgtB |
Mycobacterium avium |
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O |
- |
? |