EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + bromide |
pre-saturating the WelO5 active site with a non-native bromide anion is found to be critical to the highly selective in vitro transfer of bromine, instead of chlorine |
Hapalosiphon welwitschii |
13R-bromo-12-epi-fischerindole U + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + bromide |
pre-saturating the WelO5 active site with a non-native bromide anion is found to be critical to the highly selective in vitro transfer of bromine, instead of chlorine |
Hapalosiphon welwitschii UTEX B 1830 |
13R-bromo-12-epi-fischerindole U + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride |
- |
Fischerella ambigua |
12-epi-fischerindole G + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride |
- |
Hapalosiphon welwitschii |
12-epi-fischerindole G + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride |
the rate of conversion of 12-epi-hapalindole C to 12-epi-hapalindole E by WelO5 is less than that for conversion of 12-epi-fischerindole U to 12-epi-fischerindole G. 12-epi-fischerindole U is the preferred substrate |
Hapalosiphon welwitschii |
12-epi-fischerindole G + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride |
WelO5* from Hapalosiphon welwitschii IC-52-3 exhibits an enhanced specificity towards 12-epi-hapalindole C, a substrate poorly processed by WelO5 from Hapalosiphon welwitschii UTEX B1830, while maintaining its fidelity towards 12-epi-fischerindole U as WelO5 |
Hapalosiphon welwitschii |
12-epi-fischerindole G + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride |
WelO5* from Hapalosiphon welwitschii IC-52-3 exhibits an enhanced specificity towards 12-epi-hapalindole C, a substrate poorly processed by WelO5 from Hapalosiphon welwitschii UTEX B1830, while maintaining its fidelity towards 12-epifischerindole U as WelO5 |
Hapalosiphon welwitschii |
12-epi-fischerindole G + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride |
- |
Fischerella ambigua UTEX 1903 |
12-epi-fischerindole G + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride |
- |
Hapalosiphon welwitschii UTEX B 1830 |
12-epi-fischerindole G + succinate + CO2 + H2O |
- |
? |
1.14.20.14 | 12-epi-fischerindole U + 2-oxoglutarate + O2 + chloride |
WelO5* from Hapalosiphon welwitschii IC-52-3 exhibits an enhanced specificity towards 12-epi-hapalindole C, a substrate poorly processed by WelO5 from Hapalosiphon welwitschii UTEX B1830, while maintaining its fidelity towards 12-epifischerindole U as WelO5 |
Hapalosiphon welwitschii UTEX B 1830 |
12-epi-fischerindole G + succinate + CO2 + H2O |
- |
? |