EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.15.39 | (+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 |
- |
Streptomyces coelicolor |
(5R,S)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O |
- |
? |
1.14.15.39 | (+)-epi-isozizaene + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 |
- |
Streptomyces coelicolor A3(2) |
(5R,S)-albaflavenol + 2 oxidized [2Fe-2S] ferredoxin + H2O |
- |
? |
1.14.15.39 | (+)-epi-isozizaene + 4 reduced [2Fe-2S] ferredoxin + 4 H+ + 2 O2 |
- |
Streptomyces coelicolor |
albaflavenone + 4 oxidized [2Fe-2S] ferredoxin + 3 H2O |
- |
? |
1.14.15.39 | (+)-epi-isozizaene + 4 reduced [2Fe-2S] ferredoxin + 4 H+ + 2 O2 |
- |
Streptomyces coelicolor A3(2) M145 |
albaflavenone + 4 oxidized [2Fe-2S] ferredoxin + 3 H2O |
- |
? |
1.14.15.39 | (5R,S)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 |
- |
Streptomyces coelicolor |
albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O |
- |
? |
1.14.15.39 | (5R,S)-albaflavenol + 2 reduced [2Fe-2S] ferredoxin + 2 H+ + O2 |
- |
Streptomyces coelicolor A3(2) |
albaflavenone + 2 oxidized [2Fe-2S] ferredoxin + 2 H2O |
- |
? |
1.14.15.39 | more |
enzyme catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone. Proposed mechanism of biosynthesis of albaflavenone catalyzed by CYP170A1 |
Streptomyces coelicolor |
? |
- |
? |
1.14.15.39 | more |
the bifunctional enzyme is able to also generate farnesene isomers from farnesyl diphosphate: (E)-beta-farnesene (61%), (3E,6E)-alpha-farnesene (26%), (3Z,6E)-alpha-farnesene (6.8%), nerolidol (4.9%), and farnesol(1.8%) |
Streptomyces coelicolor |
? |
- |
? |
1.14.15.39 | more |
enzyme catalyses two sequential allylic oxidation reactions. The substrate epi-isozizaene is first oxidized to yield the epimeric intermediates (5R)-albaflavenol and (5S)-albaflavenol, which can be further oxidized to yield the sesquiterpenoid antibiotic albaflavenone. Proposed mechanism of biosynthesis of albaflavenone catalyzed by CYP170A1 |
Streptomyces coelicolor A3(2) |
? |
- |
? |
1.14.15.39 | more |
the bifunctional enzyme is able to also generate farnesene isomers from farnesyl diphosphate: (E)-beta-farnesene (61%), (3E,6E)-alpha-farnesene (26%), (3Z,6E)-alpha-farnesene (6.8%), nerolidol (4.9%), and farnesol(1.8%) |
Streptomyces coelicolor A3(2) M145 |
? |
- |
? |