EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.14.14.25 | (24S)-24-hydroxycholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Homo sapiens |
24,25-dihydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
| 1.14.14.25 | (24S)-24-hydroxycholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
- |
Homo sapiens |
24,27-dihydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
| 1.14.14.25 | (24S)-hydroxycholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
preferred substrate in vitro |
Homo sapiens |
24,25-dihydroxycholesterol + 24,27-dihydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O |
- |
? |
| 1.14.14.25 | cholesterol + NADPH + O2 |
- |
Mus musculus |
(24S)-hydroxycholesterol + NADP+ + H2O |
- |
? |
| 1.14.14.25 | cholesterol + NADPH + O2 |
- |
Homo sapiens |
(24S)-hydroxycholesterol + NADP+ + H2O |
- |
? |
| 1.14.14.25 | cholesterol + NADPH + O2 |
- |
Sus scrofa |
(24S)-hydroxycholesterol + NADP+ + H2O |
- |
? |
| 1.14.14.25 | cholesterol + NADPH + O2 |
the enzyme is important in cholesterol metabolism in the brain, cholesterol dynamics in the fetal and neonatal brain, overview |
Mus musculus |
(24S)-hydroxycholesterol + NADP+ + H2O |
the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview |
? |
| 1.14.14.25 | cholesterol + NADPH + O2 |
the enzyme is important in cholesterol metabolism in the brain, overview |
Homo sapiens |
(24S)-hydroxycholesterol + NADP+ + H2O |
the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview |
? |
| 1.14.14.25 | cholesterol + NADPH + O2 |
the enzyme is important in cholesterol metabolism in the brain, overview |
Sus scrofa |
(24S)-hydroxycholesterol + NADP+ + H2O |
the product is able to travers the blood-brain barrier, while the substrate is not, transport, and excretion of (24S)-hydroxycholesterol, oxycholesterol transport mechanisms, overview |
? |
| 1.14.14.25 | cholesterol + NADPH + O2 |
the enzyme is responsible for cholesterol elimination from brain, (24S)-hydroxycholesterol can cross the blood-brain barrier, enter the circulation, and then be delivered to the liver for further degradation, cholesterol metabolism, overview, CYP46A1 may participate in metabolism of neurosteroids and drugs that are targeted to the central nervous system |
Homo sapiens |
(24S)-hydroxycholesterol + NADP+ + H2O |
- |
? |
