EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.13.200 | tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ |
- |
Streptomyces glaucescens |
tetracenomycin C + 2 NAD(P)+ + H2O |
enzyme is responsible for the hydroxylation of tetracenomycin A2 at positions C-4, C-4a, and C-12a to give tetracenomycin C |
? |
1.14.13.200 | tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ |
- |
Streptomyces olivaceus |
tetracenomycin C + 2 NAD(P)+ + H2O |
quantitative conversion |
? |
1.14.13.200 | tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ |
biosynthesis tetracenomycin C, a polyketide antitumor antibiotic |
Streptomyces glaucescens |
tetracenomycin C + 2 NAD(P)+ + H2O |
- |
? |
1.14.13.200 | tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ |
- |
Streptomyces olivaceus Tue2353 |
tetracenomycin C + 2 NAD(P)+ + H2O |
quantitative conversion |
? |
1.14.13.200 | tetracenomycin A2 + 2 O2 + 2 NADH + 2 H+ |
tetracenomycin A2 i.e. methyl 10,12-dihydroxy-3,8-dimethoxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate. The enzyme prefers NADPH over NADH as an electron donor |
Streptomyces glaucescens |
tetracenomycin C + 2 NAD+ + H2O |
tetracenomycin C = methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate |
? |
1.14.13.200 | tetracenomycin A2 + 2 O2 + 2 NADPH + 2 H+ |
tetracenomycin A2 i.e. methyl 10,12-dihydroxy-3,8-dimethoxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate. The enzyme prefers NADPH over NADH as an electron donor |
Streptomyces glaucescens |
tetracenomycin C + 2 NADP+ + H2O |
tetracenomycin C = methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate |
? |
1.14.13.200 | tetracenomycin B2 + 2 O2 + 2 NAD(P)H + 2 H+ |
natural reaction in Streptomyces olivaceus |
Streptomyces olivaceus |
8-demethyl tetracenomycin C + 2 NAD(P)+ + H2O |
- |
? |
1.14.13.200 | tetracenomycin B2 + 2 O2 + 2 NAD(P)H + 2 H+ |
natural reaction in Streptomyces olivaceus |
Streptomyces olivaceus Tue2353 |
8-demethyl tetracenomycin C + 2 NAD(P)+ + H2O |
- |
? |