EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    1.14.11.32 | (R,S)-tetrahydropalmatine + 2-oxoglutarate + O2 |
a protoberberine, O-demethylation, 16.6% of activity with protopine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.32 | (S)-isocorydine + 2-oxoglutarate + O2 |
a aporphine, O-demethylation, 6.1% of activity with protopine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.32 | (S)-reticuline + 2-oxoglutarate + O2 |
a 1-benzylisoquinoline, O-demethylation, 16.2% of activity with protopine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.32 | (S)-scoulerine + 2-oxoglutarate + O2 |
a 1-benzylisoquinoline, O-demethylation, 70.4% of activity with protopine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.32 | allocryptopine + 2-oxoglutarate + O2 |
a protopine, O-demethylation, 50.1% of activity with protopine |
Papaver somniferum |
? |
- |
? |
| 1.14.11.32 | codeine + 2-oxoglutarate + O2 |
- |
Papaver somniferum |
morphine + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.32 | codeine + 2-oxoglutarate + O2 |
- |
Papaver orientale |
morphine + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.32 | codeine + 2-oxoglutarate + O2 |
alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde |
Papaver somniferum |
morphine + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.32 | codeine + 2-oxoglutarate + O2 |
a morphinan, O-demethylation, 89.8% of activity with protopine |
Papaver somniferum |
morphine + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.32 | cryptopine + 2-oxoglutarate + O2 |
a protopine, O-demethylation, 37.7% of activity with protopine |
Papaver somniferum |
? |
- |
? |
