EC Number |
Recommended Name |
Substrates |
Organism |
Products |
---|
5.1.99.2 | 16-hydroxysteroid epimerase |
16alpha-Hydroxyestrone |
- |
Homo sapiens |
16beta-Hydroxyestrone |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1,2-dimethyl-6-dehydroestrone + NADH |
- |
Homo sapiens |
1,2-dimethyl-6-dehydroestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1,2-dimethylestrone + NADH |
- |
Homo sapiens |
1,2-dimethylestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1-methyl-6-dehydroestrone + NADH |
- |
Homo sapiens |
1-methyl-6-dehydroestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
16-ketoestrone + NADH |
- |
Homo sapiens |
16-ketoestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
18-nor-D-homoestrone 3-methyl ether + NADH |
- |
Homo sapiens |
18-nor-D-homoestradiol 3-methyl ether + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2,4-dinitroestrone + NADH |
- |
Homo sapiens |
2,4-dinitroestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2,4-dinitroestrone 3-oxyacetic acid ether + NADH |
- |
Homo sapiens |
2,4-dinitroestradiol 3-oxyacetic acid ether + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-methoxyestrone + NADH |
- |
Homo sapiens |
2-methoxyestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-nitroestrone + NADH |
- |
Homo sapiens |
2-nitroestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-nitroestrone 3-oxyacetic acid ester + NADH + H+ |
- |
Homo sapiens |
2-nitroestradiol-17beta-3-oxyacetic acid ester + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
4-aminoestrone + NADH |
- |
Homo sapiens |
4-aminoestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
4-aminoestrone 3,4-diacetate + NADH |
- |
Homo sapiens |
4-aminoestradiol 3,4-diacetate + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
4-nitrestrone + NADH |
- |
Homo sapiens |
4-nitroestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
6-dehydroestrone 3-benzoate + NADH |
- |
Homo sapiens |
6-dehydro-17beta-estradiol 3-benzoate + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
6-ketoestrone + NADH |
- |
Homo sapiens |
6-ketoestradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
6alpha,7alpha-dihydroxyestrone + NADH |
- |
Homo sapiens |
6alpha,7alpha-dihydroxyestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
7-ketoestrone + NADH |
- |
Homo sapiens |
7-ketoestradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
7alpha-hydroxyestrone + NADH |
- |
Homo sapiens |
7alpha-hydroxyestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
7beta-hydroxyestrone + NADH |
- |
Homo sapiens |
7beta-hydroxyestradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrogenic estrone + NAD(P)H + H+ |
the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases |
Homo sapiens |
17beta-estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H |
- |
Homo sapiens |
estradiol-17beta + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H |
final step in the synthesis of active estrogens |
Homo sapiens |
estradiol-17beta + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H |
the enzyme produces active estradiol for cell proliferation |
Homo sapiens |
estradiol-17beta + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H |
- |
Homo sapiens |
estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H |
normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta. Association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion.Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy |
Homo sapiens |
estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H + H+ |
- |
Homo sapiens |
estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H + H+ |
17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours |
Homo sapiens |
estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H + H+ |
the enzyme efficiently converts estrone to estradiol and enhances the estrogen-dependent growth of cultured MCF-7 cells in the presence of hormonally less active estrone. The reaction is reversible in vitro, but in cultured cells the production of estradiol is the predominant rection in physiological conditions |
Homo sapiens |
estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H + H+ |
type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause |
Homo sapiens |
estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H + H+ |
- |
Homo sapiens |
estradiol-17beta + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H + H+ |
type 1 17beta-hydroxysteroid dehydrogenase plays a critical role in the biosynthesis of estradiol |
Homo sapiens |
estradiol-17beta + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H + H+ |
7beta-HSD type 1 |
Homo sapiens |
estradiol-17beta + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NAD(P)H + H+ |
- |
Homo sapiens |
17beta-estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH |
- |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH |
key enzyme responsible for elevated levels of 17beta-estradiol in breast tumor tissues |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH |
exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH |
17beta-estradiol is a potent stimulator of certain endocrine-dependent forms of breast cancer. The enzyme catalyzes the last step in the biosynthesis of 17beta-estradiol from the less potent estrogen, estrone |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH |
type 1 enzyme, catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH |
the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH |
trans-retinoic acid increases expression of the enzyme in a dose-dependent and time-dependent manner in T47D breast cancer cells, the increased expression is associated with an increase in reductive activity of the enzyme |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH + H+ |
- |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH + H+ |
17beta-HSD1 |
Homo sapiens |
estradiol-17beta + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH + H+ |
- |
Homo sapiens |
estradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADH + H+ |
- |
Homo sapiens |
17beta-estradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH |
- |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH |
convertion of the weak androgen estrone into the potent estrogen 17beta-estradiol |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH |
isozyme 17beta-HSD1 |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH |
the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH |
substrate of e.g. isozyme 17beta-HSD3, 17beta-HSD8, and 17beta-HSD14 |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH |
- |
Homo sapiens |
estradiol + NADP+ + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
- |
Homo sapiens |
estradiol-17beta + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone |
Homo sapiens |
estradiol-17beta + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
17beta-HSD1, final step in the synthesis of active estrogens |
Homo sapiens |
estradiol-17beta + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
final step in the synthesis of active estrogens |
Homo sapiens |
estradiol-17beta + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain |
Homo sapiens |
estradiol-17beta + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
reverse reaction catalyzed by different isoforms of the enzyme |
Homo sapiens |
estradiol-17beta + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
final step in synthesis of estradiol |
Homo sapiens |
estradiol-17beta + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
- |
Homo sapiens |
estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
kinetics demonstrates positive cooperativity |
Homo sapiens |
estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
- |
Homo sapiens |
estradiol-17beta + NADP |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
- |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
most active enzyme in regards to 17beta-estradiol production |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
the enzyme show positive cooperativity |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
- |
Homo sapiens |
17beta-estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone + NADPH + H+ |
steroid hormone pathway |
Homo sapiens |
17beta-estradiol + NAD(P)+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone 3-methyl ether + NADH |
- |
Homo sapiens |
3-O-methyl-17beta-estradiol + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estrone 3-oxyacetic acid ether + NADH |
- |
Homo sapiens |
17beta-estradiol 3-O-oxyacetic acid ether + NAD+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estronesulfate + NADPH |
- |
Homo sapiens |
17beta-estradiolsulfate + NADP+ |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
estrogenic estrone + NAD(P)H + H+ |
the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases |
Homo sapiens |
17beta-estradiol + NAD(P)+ |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
estrone + NAD(P)H + H+ |
- |
Homo sapiens |
17beta-estradiol + NAD(P)+ |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
estrone + NADPH |
estrogen activation |
Homo sapiens |
estradiol + NADP+ |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
estrone + NADPH + H+ |
- |
Homo sapiens |
17beta-estradiol + NADP+ |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
estrone + NAD(P)H + H+ |
- |
Homo sapiens |
17beta-estradiol + NAD(P)+ |
7.6.2.3 | ABC-type glutathione-S-conjugate transporter |
ATP + H2O + S-(estrone 3-sulfate)glutathione[side 1] |
substrate for isoform MRP1 |
Homo sapiens |
ADP + phosphate + S-(estrone 3-sulfate)glutathione[side 2] |
7.6.2.3 | ABC-type glutathione-S-conjugate transporter |
ATP + H2O + S-(estrone-3-sulfyl)glutathione[side 1] |
- |
Homo sapiens |
ADP + phosphate + S-(estrone-3-sulfyl)glutathione[side 2] |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + estrone-3-sulfate/in |
- |
Homo sapiens |
ADP + phosphate + estrone-3-sulfate/out |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + estrone-3-sulfate[side 1] |
- |
Homo sapiens |
ADP + phosphate + estrone-3-sulfate[side 2] |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + estrone-3-sulfate[side 1] |
substrate for BCRP |
Homo sapiens |
ADP + phosphate + estrone-3-sulfate[side 2] |
7.6.2.2 | ABC-type xenobiotic transporter |
ATP + H2O + estrone[side 1] |
substrate for MRP1 |
Homo sapiens |
ADP + phosphate + estrone[side 2] |
1.1.1.71 | alcohol dehydrogenase [NAD(P)+] |
estrone + NADPH + H+ |
- |
Homo sapiens |
? |
2.8.2.2 | alcohol sulfotransferase |
3'-phosphoadenylylsulfate + estrone |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone sulfate |
3.2.1.21 | beta-glucosidase |
estrone-3-beta-D-glucoside + H2O |
poor activity |
Homo sapiens |
beta-D-glucose + estrone |
2.8.2.14 | bile-salt sulfotransferase |
3'-phosphoadenosine-5'-phosphosulfate + oestrone |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estrone |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estrone |
SULT1E1 is involved in estrogen inactivation |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estrone |
high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estrone |
estrone sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estrone |
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estrone |
the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + estrone |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + estrone |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estrone 3-sulfate |
2.4.1.17 | glucuronosyltransferase |
2-hydroxyestrone + UDP-glucuronate |
- |
Homo sapiens |
? |
2.4.1.17 | glucuronosyltransferase |
2-hydroxyestrone + UDPglucuronate |
- |
Homo sapiens |
2-hydroxyestrone 2-O-glucuronide + UDP |
2.4.1.17 | glucuronosyltransferase |
2-hydroxyestrone + UDPglucuronate |
glucuronidated by UGT1A3 and HGT1A9 |
Homo sapiens |
2-hydroxyestrone 2-O-glucuronide + UDP |
2.4.1.17 | glucuronosyltransferase |
4-hydroxyestrone + UDP-glucuronate |
- |
Homo sapiens |
UDP + 4-hydroxyestrone 4-O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
4-hydroxyestrone + UDP-glucuronate |
- |
Homo sapiens |
UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide |
2.4.1.17 | glucuronosyltransferase |
4-hydroxyestrone + UDP-glucuronate |
- |
Homo sapiens |
? |
2.4.1.17 | glucuronosyltransferase |
estrone + UDP-glucuronate |
- |
Homo sapiens |
UDP + estrone 3-O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
estrone + UDPglucuronate |
inactive |
Homo sapiens |
UDP + estrone 3-O-glucuronide |