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Search term: estrone

Results 1 - 100 of 109 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
3(or 17)beta-hydroxysteroid dehydrogenase
estrone + NADPH
estrogen activation
estradiol + NADP+
17beta-estradiol 17-dehydrogenase
1,2-dimethyl-6-dehydroestrone + NADH
-
1,2-dimethyl-6-dehydroestradiol + NAD+
17beta-estradiol 17-dehydrogenase
1,2-dimethylestrone + NADH
-
1,2-dimethylestradiol + NAD+
17beta-estradiol 17-dehydrogenase
1,3-dimethyl-6-dehydroestrone + NADH
-
1,3-dimethyl-6-dehydroestradiol + NAD+
17beta-estradiol 17-dehydrogenase
1-methyl-6-dehydroestrone + NADH
-
1-methyl-6-dehydroestradiol + NAD+
17beta-estradiol 17-dehydrogenase
16-ketoestrone + NADH
-
16-ketoestradiol + NAD+
17beta-estradiol 17-dehydrogenase
18-nor-D-homoestrone 3-methyl ether + NADH
-
18-nor-D-homoestradiol 3-methyl ether + NAD+
17beta-estradiol 17-dehydrogenase
2,4-dinitroestrone + NADH
-
2,4-dinitroestradiol + NAD+
17beta-estradiol 17-dehydrogenase
2,4-dinitroestrone 3-oxyacetic acid ether + NADH
-
2,4-dinitroestradiol 3-oxyacetic acid ether + NAD+
17beta-estradiol 17-dehydrogenase
2-methoxyestrone + NADH
-
2-methoxyestradiol + NAD+
17beta-estradiol 17-dehydrogenase
2-nitroestrone + NADH
-
2-nitroestradiol + NAD+
17beta-estradiol 17-dehydrogenase
2-nitroestrone 3-oxyacetic acid ester + NADH + H+
-
2-nitroestradiol-17beta-3-oxyacetic acid ester + NAD+
17beta-estradiol 17-dehydrogenase
4-aminoestrone + NADH
-
4-aminoestradiol + NAD+
17beta-estradiol 17-dehydrogenase
4-aminoestrone 3,4-diacetate + NADH
-
4-aminoestradiol 3,4-diacetate + NAD+
17beta-estradiol 17-dehydrogenase
4-nitrestrone + NADH
-
4-nitroestradiol + NAD+
17beta-estradiol 17-dehydrogenase
6-dehydroestrone 3-benzoate + NADH
-
6-dehydro-17beta-estradiol 3-benzoate + NAD+
17beta-estradiol 17-dehydrogenase
6-ketoestrone + NADH
-
6-ketoestradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
6alpha,7alpha-dihydroxyestrone + NADH
-
6alpha,7alpha-dihydroxyestradiol + NAD+
17beta-estradiol 17-dehydrogenase
7-ketoestrone + NADH
-
7-ketoestradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
7alpha-hydroxyestrone + NADH
-
7alpha-hydroxyestradiol + NAD+
17beta-estradiol 17-dehydrogenase
7beta-hydroxyestrone + NADH
-
7beta-hydroxyestradiol + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H
-
estradiol-17beta + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H
final step in the synthesis of active estrogens
estradiol-17beta + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H
the enzyme produces active estradiol for cell proliferation
estradiol-17beta + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H
-
estradiol + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H
normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta. Association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion.Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy
estradiol + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H + H+
-
estradiol + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H + H+
17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours
estradiol + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H + H+
the enzyme efficiently converts estrone to estradiol and enhances the estrogen-dependent growth of cultured MCF-7 cells in the presence of hormonally less active estrone. The reaction is reversible in vitro, but in cultured cells the production of estradiol is the predominant rection in physiological conditions
estradiol + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H + H+
type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause
estradiol + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H + H+
-
estradiol-17beta + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H + H+
type 1 17beta-hydroxysteroid dehydrogenase plays a critical role in the biosynthesis of estradiol
estradiol-17beta + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NAD(P)H + H+
7beta-HSD type 1
estradiol-17beta + NAD(P)+
17beta-estradiol 17-dehydrogenase
estrone + NADH
-
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH
key enzyme responsible for elevated levels of 17beta-estradiol in breast tumor tissues
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH
exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH
17beta-estradiol is a potent stimulator of certain endocrine-dependent forms of breast cancer. The enzyme catalyzes the last step in the biosynthesis of 17beta-estradiol from the less potent estrogen, estrone
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH
type 1 enzyme, catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH
the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH
trans-retinoic acid increases expression of the enzyme in a dose-dependent and time-dependent manner in T47D breast cancer cells, the increased expression is associated with an increase in reductive activity of the enzyme
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH + H+
-
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH + H+
17beta-HSD1
estradiol-17beta + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH + H+
-
estradiol + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADH + H+
-
17beta-estradiol + NAD+
17beta-estradiol 17-dehydrogenase
estrone + NADPH
-
17beta-estradiol + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH
convertion of the weak androgen estrone into the potent estrogen 17beta-estradiol
17beta-estradiol + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH
isozyme 17beta-HSD1
17beta-estradiol + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH
the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites
17beta-estradiol + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH
substrate of e.g. isozyme 17beta-HSD3, 17beta-HSD8, and 17beta-HSD14
17beta-estradiol + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH
-
estradiol + NADP+ + H+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
-
estradiol-17beta + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone
estradiol-17beta + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
17beta-HSD1, final step in the synthesis of active estrogens
estradiol-17beta + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
final step in the synthesis of active estrogens
estradiol-17beta + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain
estradiol-17beta + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
reverse reaction catalyzed by different isoforms of the enzyme
estradiol-17beta + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
final step in synthesis of estradiol
estradiol-17beta + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
-
estradiol + NADP+
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
-
estradiol-17beta + NADP
17beta-estradiol 17-dehydrogenase
estrone + NADPH + H+
-
17beta-estradiol + NADP+
17beta-estradiol 17-dehydrogenase
estrone 3-methyl ether + NADH
-
3-O-methyl-17beta-estradiol + NAD+
17beta-estradiol 17-dehydrogenase
estrone 3-oxyacetic acid ether + NADH
-
17beta-estradiol 3-O-oxyacetic acid ether + NAD+
17beta-estradiol 17-dehydrogenase
estronesulfate + NADPH
-
17beta-estradiolsulfate + NADP+
alcohol dehydrogenase [NAD(P)+]
estrone + NADPH + H+
-
?
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
estrone + NADPH + H+
-
17beta-estradiol + NADP+
NADP-retinol dehydrogenase
estrone + NADH + H+
no substrate for wild-type, but substrate for mutant M144G
estradiol + NAD+
3alpha-hydroxysteroid 3-dehydrogenase
estrone + NAD(P)H + H+
-
17beta-estradiol + NAD(P)+
ribosyldihydronicotinamide dehydrogenase (quinone)
estrone-3,4-quinone + N-benzyldihydronicotinamide
ping-pong mechanism, NQO2 is faster in reducing estrogen quinones than its homologue NQO1
estrone-3,4-quinol + N-benzylnicotinamide
glucuronosyltransferase
2-hydroxyestrone + UDP-glucuronate
-
?
glucuronosyltransferase
2-hydroxyestrone + UDPglucuronate
-
2-hydroxyestrone 2-O-glucuronide + UDP
glucuronosyltransferase
2-hydroxyestrone + UDPglucuronate
glucuronidated by UGT1A3 and HGT1A9
2-hydroxyestrone 2-O-glucuronide + UDP
glucuronosyltransferase
4-hydroxyestrone + UDP-glucuronate
-
UDP + 4-hydroxyestrone 4-O-glucuronide
glucuronosyltransferase
4-hydroxyestrone + UDP-glucuronate
-
UDP + 4-hydroxyestrone-4-O-beta-D-glucuronide
glucuronosyltransferase
4-hydroxyestrone + UDP-glucuronate
-
?
glucuronosyltransferase
estrone + UDPglucuronate
inactive
UDP + estrone 3-O-glucuronide
glucuronosyltransferase
estrone + UDPglucuronate
glucuronidated by UGT1A3 and HGT1A9
UDP + estrone 3-O-glucuronide
glucuronosyltransferase
UDP-D-glucuronate + 2-hydroxyestrone
isozyme UGT1A1
UDP + 2-hydroxyestrone beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + 4-hydroxy-estrone
-
UDP + ?
glucuronosyltransferase
UDP-glucuronate + 2-hydroxyestrone
-
UDP + 2-hydroxyestrone beta-D-glucuronide
glucuronosyltransferase
UDP-glucuronate + 2-methoxyestrone
-
UDP + 2-methoxyestrone beta-D-glucuronide
glucuronosyltransferase
UDP-glucuronate + 4-hydroxy-estrone
glucuronidation of 4-hydroxylated estrone is significantly reduced in breast carcinomas compared to healthy
UDP + ?
glucuronosyltransferase
UDP-glucuronate + 4-methoxyestrone
-
UDP + 4-methoxyestrone beta-D-glucuronide
glucuronosyltransferase
UDP-glucuronate + estrone
-
UDP + estrone beta-D-glucuronide
glucuronosyltransferase
UDP-glucuronate + estrone
-
UDP + estrone beta-D-glucuronoside
alcohol sulfotransferase
3'-phosphoadenylylsulfate + estrone
-
adenosine 3',5'-bisphosphate + estrone sulfate
estrone sulfotransferase
3'-phosphoadenylyl sulfate + estrone
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
estrone sulfotransferase
3'-phosphoadenylyl sulfate + estrone
SULT1E1 is involved in estrogen inactivation
adenosine 3',5'-bisphosphate + estrone 3-sulfate
estrone sulfotransferase
3'-phosphoadenylyl sulfate + estrone
high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1
adenosine 3',5'-bisphosphate + estrone 3-sulfate
estrone sulfotransferase
3'-phosphoadenylyl sulfate + estrone
estrone sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor
adenosine 3',5'-bisphosphate + estrone 3-sulfate
estrone sulfotransferase
3'-phosphoadenylyl sulfate + estrone
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities
adenosine 3',5'-bisphosphate + estrone 3-sulfate
estrone sulfotransferase
3'-phosphoadenylyl sulfate + estrone
the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1
adenosine 3',5'-bisphosphate + estrone 3-sulfate
estrone sulfotransferase
3'-phosphoadenylylsulfate + estrone
-
adenosine 3',5'-bisphosphate + estrone sulfate
estrone sulfotransferase
3'-phosphoadenylylsulfate + estrone
-
adenosine 3',5'-bisphosphate + estrone 3-sulfate
bile-salt sulfotransferase
3'-phosphoadenosine-5'-phosphosulfate + oestrone
-
adenosine 3',5'-bisphosphate + estrone sulfate
steroid sulfotransferase
3'-phosphoadenylylsulfate + estrone
-
adenosine 3',5'-bisphosphate + estrone sulfate
glycochenodeoxycholate sulfotransferase
3'-phosphoadenylyl 5'-phosphosulfate + estrone
-
adenosine 3',5'-bisphosphate + estrone 7-sulfate
steryl-sulfatase
estrone 3-sulfate + H2O
-
estrone + sulfate
steryl-sulfatase
estrone 3-sulfate + H2O
hydrolyzes estrone 3-sulfate to its active, unsulfated form
estrone + sulfate
steryl-sulfatase
estrone sulfate
-
estrone + sulfate
steryl-sulfatase
estrone sulfate + H2O
-
estrone + sulfate
Results 1 - 100 of 109 > >>