EC Number |
Recommended Name |
Substrates |
Organism |
Products |
---|
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1,2-dimethylestradiol + NAD+ |
- |
Homo sapiens |
1,2-dimethylestrone + NADH |
1.10.5.1 | ribosyldihydronicotinamide dehydrogenase (quinone) |
1-benzyl-1,4-dihydronicotinamide + estradiol-3,4-quinone |
- |
Homo sapiens |
1-benzyl-3-carbamoylpyridinium + estrone-3,4-quinone |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1-methyl-6-dehydroestradiol + NAD+ |
- |
Homo sapiens |
1-methyl-6-dehydroestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1-methylestradiol + NAD+ |
- |
Homo sapiens |
1-methylestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
11alpha-hydroxyestradiol + NAD+ |
- |
Homo sapiens |
11alpha-hydroxyestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
11beta-hydroxyestradiol + NAD+ |
- |
Homo sapiens |
11beta-hydroxyestrone + NADH |
2.4.1.17 | glucuronosyltransferase |
17alpha-estradiol + UDP-alpha-D-glucuronate |
- |
Homo sapiens |
? + UDP |
2.8.2.4 | estrone sulfotransferase |
17beta-estradiol + 3'-phosphoadenylyl sulfate |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NAD(P)+ |
- |
Homo sapiens |
estrone + NAD(P)H + H+ |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
17beta-estradiol + NAD(P)H + H+ |
- |
Homo sapiens |
estrone + NAD(P)+ |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
17beta-estradiol + NAD+ |
- |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
17beta-estradiol + NAD+ |
enzyme from brain contains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
17beta-estradiol + NAD+ |
enzyme conatains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
17beta-estradiol + NAD+ |
inactivation |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NAD+ |
- |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
17beta-estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NADP+ |
isozyme 17beta-HSD4 |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH + H+ |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
17beta-estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH |
2.4.1.17 | glucuronosyltransferase |
17beta-estradiol + UDP-alpha-D-glucuronate |
- |
Homo sapiens |
? + UDP |
2.4.1.17 | glucuronosyltransferase |
17beta-estradiol + UDP-glucuronate |
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 |
Homo sapiens |
? |
3.2.1.21 | beta-glucosidase |
17beta-estradiol 17-beta-D-glucoside + H2O |
- |
Homo sapiens |
beta-D-glucose + 17beta-estradiol |
3.1.6.2 | steryl-sulfatase |
17beta-estradiol sulfate + H2O |
- |
Homo sapiens |
17beta-estradiol + sulfate |
1.1.1.147 | 16alpha-hydroxysteroid dehydrogenase |
17beta-estradiol-16-one + NAD(P)H |
- |
Homo sapiens |
16alpha-hydroxy-17beta-estradiol + NAD(P)+ |
3.2.1.21 | beta-glucosidase |
17beta-estradiol-3'-beta-D-glucoside + H2O |
poor activity |
Homo sapiens |
beta-D-glucose + 17beta-estradiol |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2,4-dinitroestradiol + NAD+ |
- |
Homo sapiens |
2,4-dinitroestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-aminoestradiol + NAD+ |
- |
Homo sapiens |
2-aminoestrone + NADH |
1.6.2.2 | cytochrome-b5 reductase |
2-hydroxyestradiol + O2 + NADH + H+ |
- |
Homo sapiens |
? |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
MB-COMT methylates both 2-hydroxyestradiol and 4-hydroxyestradiol at comparable rates |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
S-COMT methylates 2-hydroxyestradiol roughly twice as fast as it methylates 4-hydroxyestradiol |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + 2-methoxyestradiol + 2-hydroxy-3-methoxyestradiol |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
2-hydroxyestradiol 3-methyl ether + S-adenosyl-L-homocysteine |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
2-methoxyestradiol + S-adenosyl-L-homocysteine |
2.4.1.17 | glucuronosyltransferase |
2-hydroxyestradiol + UDP-glucuronate |
- |
Homo sapiens |
? |
2.4.1.17 | glucuronosyltransferase |
2-hydroxyestradiol + UDPglucuronate |
- |
Homo sapiens |
UDP + 2-hydroxyestradiol O-glucuronide |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol-17beta + S-adenosyl-L-methionine |
- |
Homo sapiens |
2-methoxyestradiol-17beta + 2-hydroxyestradiol-17beta methyl ether + S-adenosyl-L-homocysteine |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-methylestradiol + NAD+ |
- |
Homo sapiens |
2-methylestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-nitroestradiol + NAD+ |
- |
Homo sapiens |
2-nitroestrone + NADH |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17alpha-ethinylestradiol |
- |
Homo sapiens |
? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1A1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1A3 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1A2 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1C*2 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
? |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
17beta-estradiol regulates growth and differentiation in normal and malignant bone, it is inactivated to 17beta-estradiol-sulfate through SULT1E1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 17beta-estradiol |
SULT1E1 has a high affinity and catalytic efficiency for estradiol as substrate |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + 2-methoxyestradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + 2-methyl-17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 2-methyl-17beta-estradiol 3-sulfate |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate |
2.8.2.14 | bile-salt sulfotransferase |
3'-phosphoadenylyl sulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylyl sulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
SULT1E1 is involved in estrogen inactivation |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
high activity by SULT1E1, low activity by SULT1A1, EC 2.8.2.1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
isozyme SULT1E1 is specific for estradiol sulfonation, interaction of resveratrol with 17beta-estradiol, overview |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
EST expression and regulation in invasive breast cancer and ductal carcinoma in situ, overview |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
estradiol sulfate is biologically inactive, the conversion of estradiol to its sulfate prevents it from binding to and thereby activating the estrogen receptor |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
SULT1E1 acts at nanomolar concentration of estradiol. SULT1A1 is active at micromolar concentration of estradiol and has an affinity 300fold lower than SULT1E1 |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylyl sulfate + ethinyl estradiol |
a synthetic oral contraceptive, low activity |
Homo sapiens |
adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 16-hydroxy-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.2 | alcohol sulfotransferase |
3'-phosphoadenylylsulfate + 17-beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17-beta-estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha ethinyl estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17alpha ethinyl estradiol 3-sulfate |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha-estradiol |
estra-1,3,5(10)-triene-3,17alpha-diol |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.2 | alcohol sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17alpha-ethinylestradiol sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha-ethinylestradiol |
isoform SULT1A3 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 17alpha-ethynylestradiol |
celecoxib switches sulfation from the 3-O-position to the 17beta-O-position |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17alpha-ethynylestradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 17beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 17beta-estradiol |
estra-1,3,5(10)-triene-3,17alpha-diol |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 2-hydroxy-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + 4-hydroxy-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylylsulfate + beta-estradiol |
ST1A3 and ST1A5 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.1 | aryl sulfotransferase |
3'-phosphoadenylylsulfate + beta-estradiol |
no activity: ST1B2 |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.2 | alcohol sulfotransferase |
3'-phosphoadenylylsulfate + beta-estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + beta-estradiol 3-O-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + estradiol |
best substrate |
Homo sapiens |
adenosine 3',5'-bisphosphate + estradiol 3-sulfate |
2.8.2.4 | estrone sulfotransferase |
3'-phosphoadenylylsulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
2.8.2.15 | steroid sulfotransferase |
3'-phosphoadenylylsulfate + estradiol |
- |
Homo sapiens |
adenosine 3',5'-bisphosphate + ? |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
3-methyl-O-estradiol + NAD(P)+ |
- |
Homo sapiens |
3-methyl-O-estrone + NAD(P)H |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
3-O-methyl-17beta-estradiol + NAD+ |
- |
Homo sapiens |
3-O-methylestrone + NADH |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts |
Homo sapiens |
(17beta)-estra-1(10),2,4-triene-3,4,17-triol + S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
in the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase. in the isoflavone-induced. The estrogen receptor is involved in the down-regulation of COMT expression |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
MB-COMT methylates both 2-hydroxyestradiol and 4-hydroxyestradiol at comparable rates |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
S-COMT methylates 2-hydroxyestradiol roughly twice as fast as it methylates 4-hydroxyestradiol |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
? + S-adenosyl-L-homocysteine |
2.4.1.17 | glucuronosyltransferase |
4-hydroxyestradiol + UDP-glucuronate |
- |
Homo sapiens |
? |
2.4.1.17 | glucuronosyltransferase |
4-hydroxyestradiol + UDPglucuronate |
- |
Homo sapiens |
UDP + 4-hydroxyestradiol O-glucuronide |