EC Number |
Recommended Name |
Substrates |
Organism |
Products |
---|
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
17beta-estradiol + NAD+ |
- |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
17beta-estradiol + NAD+ |
enzyme from brain contains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
17beta-estradiol + NAD+ |
enzyme conatains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
17beta-estradiol + NAD+ |
inactivation |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
17beta-estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
estradiol + NAD(P)H |
- |
Homo sapiens |
estrone + NAD(P)+ |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
estradiol + NAD(P)+ |
- |
Homo sapiens |
estrone + NAD(P)H |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
estradiol + NAD+ |
- |
Homo sapiens |
estrone + NADH |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
estradiol + NADP+ |
the equilibrium state is 3% estradiol and 97% estrone |
Homo sapiens |
estrone + NADPH |
1.1.1.51 | 3(or 17)beta-hydroxysteroid dehydrogenase |
estradiol sulfate + NADP+ |
- |
Homo sapiens |
estrone sulfate + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1,2-dimethylestradiol + NAD+ |
- |
Homo sapiens |
1,2-dimethylestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1-methyl-6-dehydroestradiol + NAD+ |
- |
Homo sapiens |
1-methyl-6-dehydroestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
1-methylestradiol + NAD+ |
- |
Homo sapiens |
1-methylestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
11alpha-hydroxyestradiol + NAD+ |
- |
Homo sapiens |
11alpha-hydroxyestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
11beta-hydroxyestradiol + NAD+ |
- |
Homo sapiens |
11beta-hydroxyestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NAD(P)+ |
- |
Homo sapiens |
estrone + NAD(P)H + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NAD+ |
- |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NADP+ |
isozyme 17beta-HSD4 |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
17beta-estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2,4-dinitroestradiol + NAD+ |
- |
Homo sapiens |
2,4-dinitroestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-aminoestradiol + NAD+ |
- |
Homo sapiens |
2-aminoestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-methylestradiol + NAD+ |
- |
Homo sapiens |
2-methylestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
2-nitroestradiol + NAD+ |
- |
Homo sapiens |
2-nitroestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
3-methyl-O-estradiol + NAD(P)+ |
- |
Homo sapiens |
3-methyl-O-estrone + NAD(P)H |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
3-O-methyl-17beta-estradiol + NAD+ |
- |
Homo sapiens |
3-O-methylestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
4-nitroestradiol + NAD+ |
- |
Homo sapiens |
4-nitroestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
6alpha-hydroxyestradiol + NAD+ |
- |
Homo sapiens |
6alpha-hydroxyestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
7alpha-hydroxyestradiol + NAD+ |
- |
Homo sapiens |
7alpha-hydroxyestrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol + NAD(P)+ |
- |
Homo sapiens |
estrone + NAD(P)H |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol + NAD+ |
- |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol + NADP+ |
the equilibrium state is 92% estradiol to 8% estrone |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD(P)+ |
- |
Homo sapiens |
estrone + NAD(P)H |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD(P)+ |
17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues |
Homo sapiens |
estrone + NAD(P)H |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD(P)+ |
- |
Homo sapiens |
estrone + NAD(P)H + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD(P)+ |
17beta-HSD4 is involved in etsrogen inactivation and may protect against an excessive accumulation of E2 in human ovarian epithelial cells |
Homo sapiens |
estrone + NAD(P)H + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD(P)+ |
7beta-HSD type 2 |
Homo sapiens |
estrone + NAD(P)H + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD+ |
- |
Homo sapiens |
estrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD+ |
type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone |
Homo sapiens |
estrone + NADH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD+ |
- |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD+ |
vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. Vitamin K2 decreases the estradiol-17beta/estrone ratio in cells by 25% |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD+ |
17beta-HSD2 |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NAD+ |
enzyme catalyzes the reduction of estrone to estradiol, the rate is 2.3% of the activity with estradiol |
Homo sapiens |
estrone + NADH + H+ |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NADP+ |
- |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NADP+ |
maximal activity with NADP+ is approximately 1/3 of that with NAD+ |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NADP+ |
17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NADP+ |
reverse reaction catalyzed by different isoforms of the enzyme |
Homo sapiens |
estrone + NADPH |
1.1.1.62 | 17beta-estradiol 17-dehydrogenase |
estradiol-17beta + NADP+ |
- |
Homo sapiens |
estrone + NADPH + H+ |
1.1.1.64 | testosterone 17beta-dehydrogenase (NADP+) |
17beta-estradiol + NADP+ |
- |
Homo sapiens |
estrone + NADPH |
1.1.1.147 | 16alpha-hydroxysteroid dehydrogenase |
17beta-estradiol-16-one + NAD(P)H |
- |
Homo sapiens |
16alpha-hydroxy-17beta-estradiol + NAD(P)+ |
1.1.1.239 | 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
estradiol + NAD+ |
- |
Homo sapiens |
estrone + NADH |
1.1.1.357 | 3alpha-hydroxysteroid 3-dehydrogenase |
17beta-estradiol + NAD(P)H + H+ |
- |
Homo sapiens |
estrone + NAD(P)+ |
1.6.2.2 | cytochrome-b5 reductase |
2-hydroxyestradiol + O2 + NADH + H+ |
- |
Homo sapiens |
? |
1.10.5.1 | ribosyldihydronicotinamide dehydrogenase (quinone) |
1-benzyl-1,4-dihydronicotinamide + estradiol-3,4-quinone |
- |
Homo sapiens |
1-benzyl-3-carbamoylpyridinium + estrone-3,4-quinone |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
MB-COMT methylates both 2-hydroxyestradiol and 4-hydroxyestradiol at comparable rates |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
S-COMT methylates 2-hydroxyestradiol roughly twice as fast as it methylates 4-hydroxyestradiol |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + 2-methoxyestradiol + 2-hydroxy-3-methoxyestradiol |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
2-hydroxyestradiol 3-methyl ether + S-adenosyl-L-homocysteine |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
2-methoxyestradiol + S-adenosyl-L-homocysteine |
2.1.1.6 | catechol O-methyltransferase |
2-hydroxyestradiol-17beta + S-adenosyl-L-methionine |
- |
Homo sapiens |
2-methoxyestradiol-17beta + 2-hydroxyestradiol-17beta methyl ether + S-adenosyl-L-homocysteine |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts |
Homo sapiens |
(17beta)-estra-1(10),2,4-triene-3,4,17-triol + S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
in the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase. in the isoflavone-induced. The estrogen receptor is involved in the down-regulation of COMT expression |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
MB-COMT methylates both 2-hydroxyestradiol and 4-hydroxyestradiol at comparable rates |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
S-COMT methylates 2-hydroxyestradiol roughly twice as fast as it methylates 4-hydroxyestradiol |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
4-hydroxyestradiol + S-adenosyl-L-methionine |
- |
Homo sapiens |
? + S-adenosyl-L-homocysteine |
2.1.1.6 | catechol O-methyltransferase |
S-adenosyl-L-methionine + 1-hydroxyestradiol |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
S-adenosyl-L-methionine + 2-hydroxyestradiol |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.1.1.6 | catechol O-methyltransferase |
S-adenosyl-L-methionine + 4-hydroxyestradiol |
- |
Homo sapiens |
S-adenosyl-L-homocysteine + ? |
2.4.1.17 | glucuronosyltransferase |
17alpha-estradiol + UDP-alpha-D-glucuronate |
- |
Homo sapiens |
? + UDP |
2.4.1.17 | glucuronosyltransferase |
17beta-estradiol + UDP-alpha-D-glucuronate |
- |
Homo sapiens |
? + UDP |
2.4.1.17 | glucuronosyltransferase |
17beta-estradiol + UDP-glucuronate |
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7 |
Homo sapiens |
? |
2.4.1.17 | glucuronosyltransferase |
2-hydroxyestradiol + UDP-glucuronate |
- |
Homo sapiens |
? |
2.4.1.17 | glucuronosyltransferase |
2-hydroxyestradiol + UDPglucuronate |
- |
Homo sapiens |
UDP + 2-hydroxyestradiol O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
4-hydroxyestradiol + UDP-glucuronate |
- |
Homo sapiens |
? |
2.4.1.17 | glucuronosyltransferase |
4-hydroxyestradiol + UDPglucuronate |
- |
Homo sapiens |
UDP + 4-hydroxyestradiol O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
beta-estradiol + UDP-alpha-D-glucuronate |
- |
Homo sapiens |
beta-estradiol-3-glucuronide + UDP |
2.4.1.17 | glucuronosyltransferase |
beta-estradiol + UDP-glucuronate |
- |
Homo sapiens |
UDP + beta-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
beta-estradiol + UDP-glucuronate |
- |
Homo sapiens |
UDP + beta-estradiol 3-O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
beta-estradiol + UDP-glucuronate |
- |
Homo sapiens |
UDP + beta-estradiol-3-glucuronide |
2.4.1.17 | glucuronosyltransferase |
beta-estradiol + UDP-glucuronate |
substrate for isoform UGT1A1 |
Homo sapiens |
UDP + beta-estradiol-3-glucuronide |
2.4.1.17 | glucuronosyltransferase |
beta-estradiol + UDPglucuronate |
inactive |
Homo sapiens |
beta-estradiol-3-glucuronide + UDP |
2.4.1.17 | glucuronosyltransferase |
estradiol + UDP-alpha-D-glucuronate |
substrate of isoform UGT1A1 |
Homo sapiens |
UDP + estradiol 3-O-glucuronide |
2.4.1.17 | glucuronosyltransferase |
estradiol + UDP-glucuronate |
- |
Homo sapiens |
? |
2.4.1.17 | glucuronosyltransferase |
estradiol + UDP-glucuronate |
sigmoidal kinetics with n of 1.7 |
Homo sapiens |
estradiol 3-O-glucuronate + UDP |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + 17beta-estradiol |
- |
Homo sapiens |
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + 17beta-estradiol |
- |
Homo sapiens |
UDP + 17beta-estradiol-3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + 2-hydroxyestradiol |
isozyme UGT1A1 |
Homo sapiens |
UDP + 2-hydroxyestradiol beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + beta-D-estradiol |
isozyme UGT1A1 |
Homo sapiens |
UDP + beta-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + beta-estradiol |
- |
Homo sapiens |
UDP + beta-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + estradiol |
isozymes UGT1A1 and UGT1A9 |
Homo sapiens |
UDP + estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + estradiol |
reaction of isozyme UGT1A1 |
Homo sapiens |
UDP + estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + estradiol |
liver microsomes |
Homo sapiens |
UDP + estradiol-3-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-D-glucuronate + estradiol |
recombinant isozyme UGT1A1 |
Homo sapiens |
UDP + estradiol-3-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17-alpha-estradiol |
very low activity |
Homo sapiens |
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17-alpha-estradiol |
low activity |
Homo sapiens |
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside |
2.4.1.17 | glucuronosyltransferase |
UDP-glucuronate + 17-alpha-estradiol |
lower activity |
Homo sapiens |
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside |