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Search term: estradiol

Results 1 - 100 of 172 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
3-hydroxyacyl-CoA dehydrogenase
17beta-estradiol + NAD+
enzyme from brain contains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity
estrone + NADH
3-hydroxyacyl-CoA dehydrogenase
17beta-estradiol + NAD+
enzyme conatains 17beta-hydroxysteroid and 3alpha-hydroxysteroid dehydrogenase activity
estrone + NADH
3-hydroxyacyl-CoA dehydrogenase
17beta-estradiol + NAD+
-
estrone + NADH + H+
3-hydroxyacyl-CoA dehydrogenase
17beta-estradiol + NAD+
inactivation
estrone + NADH + H+
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
17beta-estradiol + NADP+
-
estrone + NADPH
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
estradiol + NAD(P)H
-
estrone + NAD(P)+
3(or 17)beta-hydroxysteroid dehydrogenase
estradiol + NAD(P)+
-
estrone + NAD(P)H
3(or 17)beta-hydroxysteroid dehydrogenase
estradiol + NAD+
-
estrone + NADH
3(or 17)beta-hydroxysteroid dehydrogenase
estradiol + NADP+
-
estrone + NADPH
3(or 17)beta-hydroxysteroid dehydrogenase
estradiol + NADP+
the equilibrium state is 3% estradiol and 97% estrone
estrone + NADPH
3(or 17)beta-hydroxysteroid dehydrogenase
estradiol sulfate + NADP+
-
estrone sulfate + NADPH
17beta-estradiol 17-dehydrogenase
1,2-dimethylestradiol + NAD+
-
1,2-dimethylestrone + NADH
17beta-estradiol 17-dehydrogenase
1-methyl-6-dehydroestradiol + NAD+
-
1-methyl-6-dehydroestrone + NADH
17beta-estradiol 17-dehydrogenase
1-methylestradiol + NAD+
-
1-methylestrone + NADH
17beta-estradiol 17-dehydrogenase
11alpha-hydroxyestradiol + NAD+
-
11alpha-hydroxyestrone + NADH
17beta-estradiol 17-dehydrogenase
11beta-hydroxyestradiol + NAD+
-
11beta-hydroxyestrone + NADH
17beta-estradiol 17-dehydrogenase
17beta-estradiol + NAD(P)+
-
estrone + NAD(P)H + H+
17beta-estradiol 17-dehydrogenase
17beta-estradiol + NAD+
-
estrone + NADH + H+
17beta-estradiol 17-dehydrogenase
17beta-estradiol + NADP+
-
estrone + NADPH
17beta-estradiol 17-dehydrogenase
17beta-estradiol + NADP+
isozyme 17beta-HSD4
estrone + NADPH
17beta-estradiol 17-dehydrogenase
17beta-estradiol + NADP+
-
estrone + NADPH + H+
17beta-estradiol 17-dehydrogenase
2,4-dinitroestradiol + NAD+
-
2,4-dinitroestrone + NADH
17beta-estradiol 17-dehydrogenase
2-aminoestradiol + NAD+
-
2-aminoestrone + NADH
17beta-estradiol 17-dehydrogenase
2-methylestradiol + NAD+
-
2-methylestrone + NADH
17beta-estradiol 17-dehydrogenase
2-nitroestradiol + NAD+
-
2-nitroestrone + NADH
17beta-estradiol 17-dehydrogenase
3-methyl-O-estradiol + NAD(P)+
-
3-methyl-O-estrone + NAD(P)H
17beta-estradiol 17-dehydrogenase
3-O-methyl-17beta-estradiol + NAD+
-
3-O-methylestrone + NADH
17beta-estradiol 17-dehydrogenase
4-nitroestradiol + NAD+
-
4-nitroestrone + NADH
17beta-estradiol 17-dehydrogenase
6alpha-hydroxyestradiol + NAD+
-
6alpha-hydroxyestrone + NADH
17beta-estradiol 17-dehydrogenase
7alpha-hydroxyestradiol + NAD+
-
7alpha-hydroxyestrone + NADH
17beta-estradiol 17-dehydrogenase
estradiol + NAD(P)+
-
estrone + NAD(P)H
17beta-estradiol 17-dehydrogenase
estradiol + NAD+
-
estrone + NADH + H+
17beta-estradiol 17-dehydrogenase
estradiol + NADP+
the equilibrium state is 92% estradiol to 8% estrone
estrone + NADPH
17beta-estradiol 17-dehydrogenase
estradiol + NADP+
-
estrone + NADPH + H+
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD(P)+
-
estrone + NAD(P)H
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD(P)+
17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues
estrone + NAD(P)H
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD(P)+
-
estrone + NAD(P)H + H+
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD(P)+
17beta-HSD4 is involved in etsrogen inactivation and may protect against an excessive accumulation of E2 in human ovarian epithelial cells
estrone + NAD(P)H + H+
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD(P)+
7beta-HSD type 2
estrone + NAD(P)H + H+
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD+
-
estrone + NADH
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD+
type 1 enzyme is a cytosolic isoform highly specific for estradiol. Type 2 is a membrane bound isoform reactive with both estradiol and testosterone
estrone + NADH
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD+
-
estrone + NADH + H+
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD+
vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. Vitamin K2 decreases the estradiol-17beta/estrone ratio in cells by 25%
estrone + NADH + H+
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD+
17beta-HSD2
estrone + NADH + H+
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NAD+
enzyme catalyzes the reduction of estrone to estradiol, the rate is 2.3% of the activity with estradiol
estrone + NADH + H+
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NADP+
-
estrone + NADPH
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NADP+
maximal activity with NADP+ is approximately 1/3 of that with NAD+
estrone + NADPH
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NADP+
17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity
estrone + NADPH
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NADP+
reverse reaction catalyzed by different isoforms of the enzyme
estrone + NADPH
17beta-estradiol 17-dehydrogenase
estradiol-17beta + NADP+
-
estrone + NADPH + H+
testosterone 17beta-dehydrogenase (NADP+)
17beta-estradiol + NADP+
-
estrone + NADPH
16alpha-hydroxysteroid dehydrogenase
17beta-estradiol-16-one + NAD(P)H
-
16alpha-hydroxy-17beta-estradiol + NAD(P)+
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
estradiol + NAD+
-
estrone + NADH
3alpha-hydroxysteroid 3-dehydrogenase
17beta-estradiol + NAD(P)H + H+
-
estrone + NAD(P)+
catechol O-methyltransferase
2-hydroxyestradiol + S-adenosyl-L-methionine
-
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
2-hydroxyestradiol + S-adenosyl-L-methionine
MB-COMT methylates both 2-hydroxyestradiol and 4-hydroxyestradiol at comparable rates
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
2-hydroxyestradiol + S-adenosyl-L-methionine
S-COMT methylates 2-hydroxyestradiol roughly twice as fast as it methylates 4-hydroxyestradiol
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
2-hydroxyestradiol + S-adenosyl-L-methionine
-
S-adenosyl-L-homocysteine + 2-methoxyestradiol + 2-hydroxy-3-methoxyestradiol
catechol O-methyltransferase
2-hydroxyestradiol + S-adenosyl-L-methionine
-
2-hydroxyestradiol 3-methyl ether + S-adenosyl-L-homocysteine
catechol O-methyltransferase
2-hydroxyestradiol + S-adenosyl-L-methionine
-
2-methoxyestradiol + S-adenosyl-L-homocysteine
catechol O-methyltransferase
2-hydroxyestradiol-17beta + S-adenosyl-L-methionine
-
2-methoxyestradiol-17beta + 2-hydroxyestradiol-17beta methyl ether + S-adenosyl-L-homocysteine
catechol O-methyltransferase
4-hydroxyestradiol + S-adenosyl-L-methionine
MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts
(17beta)-estra-1(10),2,4-triene-3,4,17-triol + S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
4-hydroxyestradiol + S-adenosyl-L-methionine
-
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
4-hydroxyestradiol + S-adenosyl-L-methionine
in the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase. in the isoflavone-induced. The estrogen receptor is involved in the down-regulation of COMT expression
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
4-hydroxyestradiol + S-adenosyl-L-methionine
MB-COMT methylates both 2-hydroxyestradiol and 4-hydroxyestradiol at comparable rates
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
4-hydroxyestradiol + S-adenosyl-L-methionine
S-COMT methylates 2-hydroxyestradiol roughly twice as fast as it methylates 4-hydroxyestradiol
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
4-hydroxyestradiol + S-adenosyl-L-methionine
-
? + S-adenosyl-L-homocysteine
catechol O-methyltransferase
S-adenosyl-L-methionine + 1-hydroxyestradiol
-
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
S-adenosyl-L-methionine + 2-hydroxyestradiol
-
S-adenosyl-L-homocysteine + ?
catechol O-methyltransferase
S-adenosyl-L-methionine + 4-hydroxyestradiol
-
S-adenosyl-L-homocysteine + ?
glucuronosyltransferase
17alpha-estradiol + UDP-alpha-D-glucuronate
-
? + UDP
glucuronosyltransferase
17beta-estradiol + UDP-alpha-D-glucuronate
-
? + UDP
glucuronosyltransferase
17beta-estradiol + UDP-glucuronate
metabilized by mutant enzyme S432G-UGT1A7, but not by wild-type enzyme UGT1A7
?
glucuronosyltransferase
2-hydroxyestradiol + UDP-glucuronate
-
?
glucuronosyltransferase
2-hydroxyestradiol + UDPglucuronate
-
UDP + 2-hydroxyestradiol O-glucuronide
glucuronosyltransferase
4-hydroxyestradiol + UDP-glucuronate
-
?
glucuronosyltransferase
4-hydroxyestradiol + UDPglucuronate
-
UDP + 4-hydroxyestradiol O-glucuronide
glucuronosyltransferase
beta-estradiol + UDP-alpha-D-glucuronate
-
beta-estradiol-3-glucuronide + UDP
glucuronosyltransferase
beta-estradiol + UDPglucuronate
inactive
beta-estradiol-3-glucuronide + UDP
glucuronosyltransferase
estradiol + UDP-alpha-D-glucuronate
substrate of isoform UGT1A1
UDP + estradiol 3-O-glucuronide
glucuronosyltransferase
estradiol + UDP-glucuronate
-
?
glucuronosyltransferase
estradiol + UDP-glucuronate
sigmoidal kinetics with n of 1.7
estradiol 3-O-glucuronate + UDP
glucuronosyltransferase
UDP-D-glucuronate + 17beta-estradiol
-
UDP + 17beta-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + 17beta-estradiol
-
UDP + 17beta-estradiol-3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + 2-hydroxyestradiol
isozyme UGT1A1
UDP + 2-hydroxyestradiol beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + beta-D-estradiol
isozyme UGT1A1
UDP + beta-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + beta-estradiol
-
UDP + beta-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + estradiol
isozymes UGT1A1 and UGT1A9
UDP + estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + estradiol
reaction of isozyme UGT1A1
UDP + estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + estradiol
liver microsomes
UDP + estradiol-3-beta-D-glucuronoside
glucuronosyltransferase
UDP-D-glucuronate + estradiol
recombinant isozyme UGT1A1
UDP + estradiol-3-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17-alpha-estradiol
very low activity
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17-alpha-estradiol
low activity
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17-alpha-estradiol
lower activity
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17-alpha-estradiol
very high activity with UGT1A10
UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17-beta-estradiol
-
UDP + 17-beta-estradiol 3-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17-beta-estradiol
low activity
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17-beta-estradiol
lower activity
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17-beta-estradiol
very high activity
UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
glucuronosyltransferase
UDP-glucuronate + 17beta-estradiol
-
UDP + 17beta-estradiol 3-O-glucuronide
Results 1 - 100 of 172 > >>