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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.64(R)-3-hydroxybutanoyl-CoA poor substrate Aquincola tertiaricarbonis 2-hydroxy-2-methylpropanoyl-CoA - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.64(R)-3-hydroxybutanoyl-CoA 2-hydroxy-2-methylpropanoyl i.e. 2-hydroxyisobutanoyl-CoA. 2-Hydroxyisobutanoyl-CoA is predominantly converted to (S)-3-hydroxybutanoyl-CoA, and only minor amounts of about 20% of the (R)-enantiomer are obtained Aquincola tertiaricarbonis 2-hydroxy-2-methylpropanoyl-CoA - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.64(R)-3-hydroxybutanoyl-CoA very low activity with wild-type enzyme. Mutations D117V or D117A in the large subunit HcmA result in significantly increased activity toward (R)-3-hydroxybutyryl-CoA Aquincola tertiaricarbonis 2-hydroxy-2-methylpropanoyl-CoA - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.64(S)-3-hydroxybutanoyl-CoA - Aquincola tertiaricarbonis 2-hydroxy-2-methylpropanoyl-CoA - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.64(S)-3-hydroxybutanoyl-CoA favorite substrate Aquincola tertiaricarbonis 2-hydroxy-2-methylpropanoyl-CoA - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.642,2-dimethylpropanoyl-CoA wild-type enzyme as well as I90V (HcmA) and I90A (HcmA) mutant enzymes can also isomerize pivaloyl-CoA and isovaleryl-CoA, albeit at more than 10times lower rates than the favorite substrate (S)-3-hydroxybutyryl-CoA Aquincola tertiaricarbonis ? - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.642-hydroxy-2-methylpropanoyl-CoA - Aquincola tertiaricarbonis (S)-3-hydroxybutanoyl-CoA - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.642-hydroxy-2-methylpropanoyl-CoA the enzym plays a central role in the degradation of assorted substrates containing a tert-butyl moiety Aquincola tertiaricarbonis (S)-3-hydroxybutanoyl-CoA - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.642-hydroxy-2-methylpropanoyl-CoA 2-hydroxy-2-methylpropanoyl i.e. 2-hydroxyisobutanoyl-CoA. 2-Hydroxyisobutanoyl-CoA is predominantly converted to (S)-3-hydroxybutanoyl-CoA, and only minor amounts of about 20% of the (R)-enantiomer are obtained, indicating stereospecific catalysis. The enzyme uses radical chemistry to rearrange the positions of both a methyl group and a hydroxyl group. Compared with Vmax obtained with 2-hydroxyisobutanoyl-CoA, rates with (S)-3-hydroxybutanoyl-CoA are nearly four times higher Aquincola tertiaricarbonis (S)-3-hydroxybutanoyl-CoA - r
Display the word mapDisplay the reaction diagram Show all sequences 5.4.99.64butanoyl-CoA low rearrangement activity, corresponding to approximately 2% of the (S)-3-hydroxybutanoyl-CoA conversion rate Aquincola tertiaricarbonis isobutanoyl-CoA - r
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