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Results 1 - 10 of 27 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
(R)-3-hydroxybutanoyl-CoA
poor substrate
2-hydroxy-2-methylpropanoyl-CoA
-
r
(R)-3-hydroxybutanoyl-CoA
2-hydroxy-2-methylpropanoyl i.e. 2-hydroxyisobutanoyl-CoA. 2-Hydroxyisobutanoyl-CoA is predominantly converted to (S)-3-hydroxybutanoyl-CoA, and only minor amounts of about 20% of the (R)-enantiomer are obtained
2-hydroxy-2-methylpropanoyl-CoA
-
r
(R)-3-hydroxybutanoyl-CoA
very low activity with wild-type enzyme. Mutations D117V or D117A in the large subunit HcmA result in significantly increased activity toward (R)-3-hydroxybutyryl-CoA
2-hydroxy-2-methylpropanoyl-CoA
-
r
(R)-3-hydroxybutanoyl-CoA
2-hydroxy-2-methylpropanoyl i.e. 2-hydroxyisobutanoyl-CoA. 2-Hydroxyisobutanoyl-CoA is predominantly converted to (S)-3-hydroxybutanoyl-CoA, and only minor amounts of about 20% of the (R)-enantiomer are obtained
2-hydroxy-2-methylpropanoyl-CoA
-
r
(R)-3-hydroxybutanoyl-CoA
catalytic efficiency for the (R)-enantiomer is about 11 times higher than for the (S)-enantiomer
2-hydroxybutanoyl-CoA
-
r
(S)-3-hydroxybutanoyl-CoA
-
2-hydroxy-2-methylpropanoyl-CoA
-
r
(S)-3-hydroxybutanoyl-CoA
-
2-hydroxy-2-methylpropanoyl-CoA
-
r
(S)-3-hydroxybutanoyl-CoA
favorite substrate
2-hydroxy-2-methylpropanoyl-CoA
-
r
(S)-3-hydroxybutanoyl-CoA
-
2-hydroxy-2-methylpropanoyl-CoA
-
r
(S)-3-hydroxybutanoyl-CoA
catalytic efficiency for the (R)-enantiomer is about 11 times higher than for the (S)-enantiomer
2-hydroxybutanoyl-CoA
-
r
Results 1 - 10 of 27 > >>