EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
    5.3.3.2 | 3-cyclopropyl-3-buten-1-yl diphosphate |
- |
Staphylococcus aureus |
(2Z)-3-cyclopropylbut-2-en-1-yl diphosphate |
- |
r |
| 5.3.3.2 | (Z)-3-(difluoromethyl)-2-buten-1-yl diphosphate |
about 2% of the activity with isopenteyl diphosphate |
Thermus thermophilus |
? |
- |
? |
| 5.3.3.2 | (Z)-3-(fluoromethyl)-2-buten-1-yl diphosphate |
about 2% of the activity with isopenteyl diphosphate |
Thermus thermophilus |
? |
- |
? |
| 5.3.3.2 | 3-(fluoromethyl)-3-buten-1-yl diphosphate |
competition between isomerization and alkylation of the flavin cofactor |
Thermus thermophilus |
? |
- |
? |
| 5.3.3.2 | 3-methylene-4-penten-1-yl diphosphate |
competition between isomerization and alkylation of the flavin cofactor |
Thermus thermophilus |
? |
- |
? |
| 5.3.3.2 | Isopentenyl diphosphate |
- |
Saccharomyces cerevisiae |
? |
- |
? |
| 5.3.3.2 | Isopentenyl diphosphate |
- |
Schizosaccharomyces pombe |
? |
- |
? |
| 5.3.3.2 | Isopentenyl diphosphate |
essential activation step in isoprenoid biosynthetic pathway |
Homo sapiens |
? |
- |
? |
| 5.3.3.2 | more |
the enzyme also has NADH dehydrogenase activity although it catalyzes the isomerase reaction without consuming any detectable amount of NADH. O2 acts as electron acceptor in the NADH dehydrogenase reaction |
Saccharolobus shibatae |
? |
- |
? |
| 5.3.3.2 | more |
zinc is located in an unusual six-coordinate pocket and may facilitate protonation of the unactivated carbon-carbon double bond in isopentenyl diphosphate. The sulfhydryl moiety C67, perhaps in the thiolate form, is in position to remove a proton from the resulting tertiary carbocation to complete the reaction |
Escherichia coli |
? |
- |
? |
