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Results 1 - 5 of 5
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
5,6,7,8-tetrahydromethanopterin + formaldehyde
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5,10-methylenetetrahydromethanopterin + H2O
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?
glutathione + formaldehyde
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S-(hydroxymethyl)glutathione
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?
more
the enzyme glutathione-dependent formaldehyde-activating enzyme (GFA) from Paracoccus denitrificans catalyzes S-hydroxymethylglutathione (HMG) formation from glutathione and formaldehyde. Enzyme GFA binds glutathione but does not directly catalyse HMG formation under standard conditions. It is possible that GFA acts as a glutathione carrier that acts to co-localise glutathione and formaldehyde in a cellular context. NMR exchange spectroscopy is used for ligand identification. Glutathione binding structure, overview
?
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S-(hydroxymethyl)glutathione
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glutathione + formaldehyde
-
?
S-(hydroxymethyl)glutathione
the enzyme accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway
glutathione + formaldehyde
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?
Results 1 - 5 of 5