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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B92'-deoxycytidine + H2O in ssDNA Homo sapiens 2'-deoxyuridine + NH3 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B95'-AAAGAGAAAGAGAAACCCAAAGAGGAAAGGTGAGGAGAA-3' + H2O the enzyme targets 5'-CCCA-3' sequences with 5'-AAACCCAAA-3' recognized most efficiently Homo sapiens 5'-AAAGAGAAAGAGAAACCUAAAGAGGAAAGGTGAGGAGAA-3' + NH3 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B95'-ATTCCCAATT-3' + H2O - Homo sapiens 5'-ATTCCUAATT-3' - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B95-methylcytosine in single-stranded DNA + H2O the enzyme exhibits low activity toward 5-methylcytosine n single-stranded DNA Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9cytidine in HIV-1 virus ssDNA + H2O - Homo sapiens uridine in HIV-1 virus ssDNA + NH3 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9cytosine in single-stranded DNA + H2O - Homo sapiens uracil in single-stranded DNA + NH3 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9cytosine in single-stranded DNA + H2O the APOBEC3 enzymes are a double-edged sword that can catalyze deamination of cytosine in genomic DNA, which results in potential genomic instability due to the many mutagenic fates of uracil. The enzymes must be able to efficiently deaminate transiently available single-stranded DNA during reverse transcription, replication, or transcription. Specific biochemical characteristics promote deamination in each situation to increase enzyme efficiency through processivity, rapid enzyme cycling between substrates, or oligomerization state Homo sapiens uracil in single-stranded DNA + NH3 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9cytosine in single-stranded DNA + H2O the enzyme restricts the infectivity of viruses, such as HIV-1, by targeting CCC hotspots scattered through minus DNA strands, reverse-transcribed from genomic RNA Homo sapiens uracil in single-stranded DNA + NH3 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9cytosine in single-stranded DNA + H2O relatively low deaminase activity and selectivity for methylated cytosine Homo sapiens uracil in single-stranded DNA + NH3 - ?
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9cytosine in single-stranded DNA + H2O the enzyme preferentially converts cytidine to uridine at the third position of triplet cytosine (CCC) hotspots. The phosphate backbone is required for C-terminal domain of the enzyme to slide along the DNA strand and to exert the 3'->5' polarity. The higher the salt cncentration, the less prominent is the 3'->5' polarity Homo sapiens uracil in single-stranded DNA + NH3 - ?
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