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Results 1 - 10 of 27 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
(di-SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O
SENP7 displays isopeptidase activity against di-SUMO-2- and SUMO-2-modified Ran GTPase-activating protein 1 but has limited activity against SUMO-1-modified Ran GTPase-activating protein 1
?
-
?
(SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O
SENP7 displays isopeptidase activity against di-SUMO-2- and SUMO-2-modified Ran GTPase-activating protein 1 but has limited activity against SUMO-1-modified Ran GTPase-activating protein 1
?
-
?
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
SENP6 and SENP7 prefer SUMO2 or SUMO3 in deconjugation reactions with rates comparable with those catalyzed by SENP2. In contrast to SENP2, SENP6 and SENP7 are less able to deconjugate SUMO1-RanGAP1, and products are only detected at enzyme concentrations 100 x higher than that observed for reactions containing SENP2
SUMO-3 + Ran GTPase-activating protein 1
-
?
acetyl-LRGG-7-amido-4-trifluoromethylcoumarin + H2O
SENP7 prefers the LRGG sequence, residues typical of Nedd8 or ubiquitin in the P3 and P4 positions
acetyl-LRGG + 7-amino-4-trifluoromethylcoumarin
-
?
acetyl-QTGG-7-amido-4-trifluoromethylcoumarin + H2O
very low activity
acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin
-
?
di-SUMO-2 + H2O
-
2 SUMO-2
-
?
di-SUMO-3 + H2O
-
2 SUMO-3
-
?
more
SENP7 has a restricted substrate specificity, being unable to process SUMO precursors and displaying paralogue-specific isopeptidase activity
?
-
-
more
SENP7 reveals no detectable endopeptidase activity on the precursors of ubiquitin, Nedd8 and ISG15
?
-
-
more
a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent
?
-
-
Results 1 - 10 of 27 > >>