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EC Number
Substrates
Commentary Substrates
Products
Commentary (Products)
Reversibility
3.4.22.64
procaspase-3 + H2O
-
?
-
?
3.4.22.64
procaspase-3 + H2O
the enzyme is a critical initiator caspase responsible for the activation of caspase-3
?
-
?
3.4.22.64
procaspase-1 + H2O
the enzyme is an upstream activator of caspase-1
?
-
?
3.4.22.64
procaspase-1 + H2O
-
?
-
?
3.4.22.64
Pro-interleukin-1beta + H2O
-
?
-
?
3.4.22.64
mouse interleukin-18 + H2O
low activity
?
-
?
3.4.22.64
more
optimal cleavage site is IEHD, LEHD, VEHD or PEHD
?
-
?
3.4.22.64
more
-
?
-
?
3.4.22.64
more
overexpression induces apoptosis
?
-
?
3.4.22.64
more
phenotype of animals deficient in caspase-11: resistant to lipopolysaccharide-induced caspase-1 processing, interleukin-1alpha and interleukin-beta secretion, and endotoxic shock
?
-
?
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