EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
   3.4.21.B26 | alpha-dystroglycan + H2O |
cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP). Full-length alpha-dystroglycan in the human endometrial epithelium is a barrier for embryo attachment and removal of the N-terminus by proprotein convertase 5/6 regulates receptivity. Removal of alpha-dystroglycan N-terminus is an important posttranslational control of endometrial receptivity and uterine fluid |
Homo sapiens |
? |
- |
? |
| 3.4.21.B26 | alpha-dystroglycan + H2O |
cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP) |
Homo sapiens |
? |
- |
? |
| 3.4.21.B26 | ANKKPPLPKRVRRQIHATPTP + H2O |
a peptide representing alpha-dystroglycan amino acids 299-319 that encompasses the predicted PC6-cleavage site (ANKKPPLPKRVRR312-/-QIHATPTP) |
Homo sapiens |
ANKKPPLPKRVRR + QIHATPTP |
- |
? |
| 3.4.21.B26 | more |
both isoforms can cleave a number of fluorogenic substrates of general formula Arg/Lys-(Xaa)n-(Arg)-, where n= 2, 4, or 6 |
Homo sapiens |
? |
- |
? |
| 3.4.21.B26 | more |
substrate cleavage analysis. Strong preference of Arg at position P1 and P4 |
Homo sapiens |
? |
- |
? |
| 3.4.21.B26 | more |
development of a high-throughput immunohistochemic assay for human proprotein convertase 5/6 for detecting uterine receptivity, method evaluation, overview |
Homo sapiens |
? |
- |
? |
| 3.4.21.B26 | PCSK9 + H2O |
PC5/6A inactivates PCSK9 by cleavage at the motif RFHR218 |
Homo sapiens |
PCSK9-DELTAN218 + ? |
- |
? |
| 3.4.21.B26 | pGlu-Arg-Thr-Lys-Arg-methyl-7-amido-4-methylcoumarin + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.4.21.B26 | pro-integrin-alpha5 + H2O |
cleavage of the substrate into its heavy and light chains |
Homo sapiens |
active integrin-alpha5 + ? |
- |
? |
| 3.4.21.B26 | pro-integrin-alphaV + H2O |
cleavage of the substrate into its heavy and light chains |
Homo sapiens |
active integrin-alphaV + ? |
- |
? |
