EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
   3.1.1.84 | (-)-cocaine + H2O |
- |
Homo sapiens |
ecgonine methyl ester + benzoate |
- |
? |
| 3.1.1.84 | (-)-cocaine + H2O |
- |
Homo sapiens |
benzoic acid + methyl (1R,2R,3S,5S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]-octane-2-carboxylate |
i.e. ecgonine methyl ester |
? |
| 3.1.1.84 | (-)-cocaine + H2O |
- |
Homo sapiens |
benzoic acid + methyl-(1R,2R,3S,5S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]-octane-2-carboxylate |
i.e. ecgonine methyl ester |
? |
| 3.1.1.84 | 4-methylumbelliferyl acetate + H2O |
hCE-2 has higher catalytic efficiency for hydrolysis than hCE-1 |
Homo sapiens |
4-methylumbelliferone + acetate |
- |
? |
| 3.1.1.84 | 6-monoacetylmorphine + H2O |
- |
Homo sapiens |
morphine + acetate |
- |
? |
| 3.1.1.84 | 6-monoacetylmorphine + H2O |
hCE-2 has higher catalytic efficiency for hydrolysis than hCE-1 |
Homo sapiens |
morphine + acetate |
- |
? |
| 3.1.1.84 | cocaine + H2O |
hCE-2 exhibits different drug ester substrate specificity from the human liver carboxylesterase hCE-1, which hydrolyzes the methyl ester of cocaine. hCE-2 may play an important role in the degradation of cocaine and heroin in human tissues |
Homo sapiens |
ecgonine methyl ester + benzoate |
- |
? |
| 3.1.1.84 | cocaine + H2O |
hCE-2 exhibits different drug ester substrate specificity from the human liver carboxylesterase hCE-1, which hydrolyzes the methyl ester of cocaine |
Homo sapiens |
ecgonine methyl ester + benzoate |
- |
? |
| 3.1.1.84 | heroin + H2O |
- |
Homo sapiens |
6-monoacetylmorphine + acetate |
- |
? |
| 3.1.1.84 | heroin + H2O |
hCE-2 has higher catalytic efficiency for hydrolysis than hCE-1 |
Homo sapiens |
6-monoacetylmorphine + acetate |
- |
? |
