Refine search

Search Substrates and Products (Substrate)

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 10 of 34 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
(-)-cocaine + H2O
-
ecgonine methyl ester + benzoate
-
?
(-)-cocaine + H2O
-
ecgonine methyl ester + benzoate
-
?
(-)-cocaine + H2O
(-)-cocaine is the naturally occurring enantiomer. The entire hydrolysis reaction consists of four reaction steps, including the nucleophilic attack on the carbonyl carbon of benzoyl ester group by the hydroxyl group of Ser117, dissociation of benzoyl ester group, nucleophilic attack on the carbonyl carbon of benzoyl ester group by water, and finally dissociation between the (-)-cocaine benzoyl group and Ser117 of CocE. The third reaction step involving the nucleophilic attack of a water molecule is rate-determining
ecgonine methyl ester + benzoate
-
?
(-)-cocaine + H2O
-
benzoic acid + methyl (1R,2R,3S,5S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]-octane-2-carboxylate
i.e. ecgonine methyl ester
?
(-)-cocaine + H2O
-
benzoic acid + methyl-(1R,2R,3S,5S)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]-octane-2-carboxylate
i.e. ecgonine methyl ester
?
4-methylumbelliferyl acetate + H2O
hCE-2 has higher catalytic efficiency for hydrolysis than hCE-1
4-methylumbelliferone + acetate
-
?
6-monoacetylmorphine + H2O
-
morphine + acetate
-
?
6-monoacetylmorphine + H2O
hCE-2 has higher catalytic efficiency for hydrolysis than hCE-1
morphine + acetate
-
?
cocaethylene + H2O
cocaethylene is a more potent cocaine metabolite, observed in patients who concurrently abuse cocaine and alcohol
?
-
?
cocaine + H2O
-
ecgonine methyl ester + benzoate
-
?
Results 1 - 10 of 34 > >>