EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   3.1.1.106 | mono-ADP-ribosylated phosphorylated double stranded DNA ends + H2O |
the enzyme can efficiently remove ADP-D-ribose from 5' and 3'-phosphorylated double stranded DNA adducts in vitro |
Homo sapiens |
? |
- |
? |
| 3.1.1.106 | mono-ADP-ribosylated phosphorylated double stranded DNA ends + H2O |
the enzyme can efficiently remove ADP-D-ribose from 5' and 3'-phosphorylated double stranded DNA adducts in vitro |
Mus musculus |
? |
- |
? |
| 3.1.1.106 | more |
isoform MacroD1 is completely inactive toward poly-ADP-D-ribose synthesized by ADP-ribosyltransferase diphtheria toxin-like 1 in the presence of high NAD+ concentrations |
Homo sapiens |
? |
- |
? |
| 3.1.1.106 | more |
isoform MacroD2 is a mono-ADP-ribosylhydrolase specific for acidic residues of aspartates and glutamates |
Homo sapiens |
? |
- |
? |
| 3.1.1.106 | more |
isoform MacroD2 is completely inactive toward poly-ADP-D-ribose synthesized by ADP-ribosyltransferase diphtheria toxin-like 1 in the presence of high NAD+ concentrations. MacroD2 does not remove ADP-D-ribose modifications generated by the arginine-specific enzyme CDTa or TccC3 |
Homo sapiens |
? |
- |
? |
| 3.1.1.106 | more |
neither 2''- nor 3''-N-acetyl-ADP-D-ribose is a substrate for the enzyme |
Homo sapiens |
? |
- |
? |
| 3.1.1.106 | more |
no activity with ADP-ribosylated thymidine on single stranded DNA |
Homo sapiens |
? |
- |
? |
| 3.1.1.106 | more |
no activity with ADP-ribosylated thymidine on single stranded DNA |
Mus musculus |
? |
- |
? |
| 3.1.1.106 | poly(ADP-D-ribose) + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.1.1.106 | poly(ADP-D-ribose) + H2O |
the linkage hydrolyzed by the enzyme in poly(ADP-D-ribose) is stereospecific at the C-1' position with the alpha-anomer present in the polymer |
Homo sapiens |
ADP-D-ribose |
- |
? |
