EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.8.29 | 1,2-diacylphosphatidylethanolamine + L-serine |
the substrate is 6times better utilized than phosphatidylethanolamine plasmalogen |
Mus musculus |
? |
- |
? |
2.7.8.29 | L-1-phosphatidylethanolamine + L-serine |
- |
Mus musculus |
L-1-phosphatidylserine + ethanolamine |
- |
? |
2.7.8.29 | L-1-phosphatidylethanolamine + L-serine |
- |
Cricetulus griseus |
L-1-phosphatidylserine + ethanolamine |
- |
? |
2.7.8.29 | L-1-phosphatidylethanolamine + L-serine |
- |
Homo sapiens |
L-1-phosphatidylserine + ethanolamine |
- |
? |
2.7.8.29 | more |
no substrate: phosphatidylcholine |
Homo sapiens |
? |
- |
? |
2.7.8.29 | more |
the enzyme synthesizes docosahexaenoic acid-phosphatidylserine much more efficiently than phosphatidylserine containing either 18:1 or 20:4 at the sn-2 position. Although no sn-1 fatty acyl preference is noted, phosphatidylserine synthase 2 exhibits significant preference toward docosahexaenoic acid compared with 18:1 or 20:4 at the sn-2 position |
Mus musculus |
? |
- |
? |
2.7.8.29 | more |
isozyme PSS1 shows a 2fold higher preference for sn-1 18:0 compared with 16:0 when the sn-2 position contains 18:1 |
Mus musculus |
? |
- |
? |
2.7.8.29 | more |
the recombinant FLAG-tagged enzyme is also active with phosphatidylethanolamine plasmalogen, [C18(plasm),22:6-PS], which is six times less effective as a substrate than the corresponding ester-linked phosphatidylethanolamine species, the isozyme is active with oleic acid (OA; 18:1n-9), DHA (DHA; 22:6n-3), or arachidonic acid esters. Compounds analysis by mass spectroscopy. A carbonyl group next to the glycerol backbone in the substrate-binding pocket substantially increases the catalytic activity of PSS2. Isozyme PSS2 shows a 10fold preference for sn-1 18:0, when 22:6 is esterified at the sn-2 position. Synthesis of 18:0,22:6-PS is most efficient compared with 18:0,18:1-PS and with 18:0,20:4-PS. Substrate specificity and acyl chain preference of isozyme PS2, overview |
Mus musculus |
? |
- |
? |
2.7.8.29 | phosphatidylethanolamine plasmalogen + L-serine |
- |
Mus musculus |
? |
- |
? |
2.7.8.29 | L-1-phosphatidylcholine + L-serine |
isozyme PSS1 |
Mus musculus |
L-1-phosphatidylserine + choline |
- |
r |