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Results 1 - 6 of 6
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
ATP + TPHE39A
truncated tRNA consisting of 39 nucleotides derived from tRNAPhe, minimal RNA substrate for modification by ThiI. The crystal structure of TPHE39A shows that base pairs in the T-stem are almost completely disrupted, although those in the acceptor-stem are preserved. ThiI can efficiently bind with not only tRNAPhe but also TPHE39A
adenylated TPHE39A + diphosphate
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?
more
ThiI is involved in the modification of uridine to 4-thiouridine
?
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more
ThiI plays a role in the transfer of sulfur from cysteine to both thiamine and 4-thiouridine
?
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-
tRNA-uridine + ATP
-
adenylated-trNA-uridine + diphosphate
-
?
tRNA-uridine + ATP
based upon sequence alignments, ThiI shares a unique P-loop motif with the PPi synthetase family. ThiI very likely catalyzes the adenylation of a substrate, probably a molecule bearing a carbonyl oxygen
adenylated-trNA-uridine + diphosphate
-
?
tRNA-uridine + GTP
kcat/Km for GTP is about 6fold lower than the value for ATP
adenylated-trNA-uridine + diphosphate
-
?
Results 1 - 6 of 6