EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   2.7.12.2 | more |
- |
Schizosaccharomyces pombe |
? |
- |
? |
| 2.7.12.2 | more |
Pek1, in its unphosphorylated form, acts as a potent negative regulator of Pmk1 MAPK signalling. Mkh1, an upstream MAPKK kinase, converts Pek1 from being an inhibitor to an activator. Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state |
Schizosaccharomyces pombe |
? |
- |
? |
| 2.7.12.2 | more |
MEKK3 activates SEK and MEK, the known kinases targeting SAPK and ERK respectively |
Homo sapiens |
? |
- |
? |
| 2.7.12.2 | more |
enzyme is part of mitogen-activated protein kinase pathways, crosstalk and regulation mechanism, overview |
eukaryota |
? |
- |
? |
| 2.7.12.2 | more |
the enzyme performs autophosphorylation |
Leishmania mexicana |
? |
- |
? |
| 2.7.12.2 | more |
MEK1/2 are involved in the mitogen-activated protein kinase signaling pathway and in cancer tumorigenesis |
Homo sapiens |
? |
- |
? |
| 2.7.12.2 | more |
the enzyme is involved in the mitogen-activated protein kinase signaling pathway |
Rattus norvegicus |
? |
- |
? |
| 2.7.12.2 | more |
the enzyme is involved in the mitogen-activated protein kinase signaling pathway regulating cell dissociation of cancer cells, MEK2 is an invasion-metastasis related factor between highly and weakly invasive cells, occludin acts as antagonist |
Mesocricetus auratus |
? |
- |
? |
| 2.7.12.2 | more |
the enzyme is involved in the mitogen-activated protein kinase signaling pathway, pathway induction by neurotrophin stabilizes the axonal growth cone, pathway inhibitor semaphorin 3F induces growth cone collaps in sympathetic neurons and reduction of axonal growth |
Rattus norvegicus |
? |
- |
? |
| 2.7.12.2 | more |
the enzyme is involved in the mitogen-activated protein kinase signaling pathway, which is involved in e.g. activation of Egr-1 and subsequently of c-Fos and cyclin D1 after mechanic injury for induction/regulation of regrowth of smooth vascular cells, vascular smooth muscle cell proliferation plays an important role in pathogenesis of atherosclerosis and post-angioplasty restenosis, overview |
Rattus norvegicus |
? |
- |
? |
