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Results 1 - 10 of 142 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
ATP + [IkappaB protein]
-
ADP + [IkappaB phosphoprotein]
-
?
ATP + a protein
CHUK associates with the NF-kappaB inhibitory protein, IkappaB-alpha, in mammalian cells. CHUK specifically phosphorylates IkappaB-alpha on both Ser32 and Ser36, modifications that are required for targeted degradation of IkappaB-alpha via the ubiquitin-proteasome pathway
ADP + a phosphoprotein
-
?
ATP + a protein
the I kappa B/NF-kappa B system is a key determinant of mucosal inflammation and protection
ADP + a phosphoprotein
-
-
ATP + a protein
phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB
ADP + a phosphoprotein
-
?
ATP + a protein
phosphorylates IkappaB inhibitory proteins, causing their degradation and activation of transcription factor NF-kappaB, a master activator of inflammatory responses
ADP + a phosphoprotein
-
?
ATP + Bcl
phosphorylation at the C-terminus of Bcl by IKKbeta disrupts Bcl10/Malt1 association and Bcl10-mediated signaling
ADP + phosphorylated Bcl
-
?
ATP + Bcl
phosphorylation at the C-terminus of Bcl by IKKbeta, inactive with a C-terminal 93 amino acid-deletion mutant of Bcl
ADP + phosphorylated Bcl
-
?
ATP + Bcl
Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl
ADP + phosphorylated Bcl10
-
?
ATP + Bcl10
negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview
ADP + phosphorylated Bcl10
-
?
ATP + GST-IkappaBalpha
activity assay
ADP + GST-IkappaBalpha phosphoprotein
-
?
Results 1 - 10 of 142 > >>