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Results 1 - 10 of 192 > >>
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30integrin alpha7 + NAD+ the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 N-terminal ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin activation status of integrin alpha7beta1 in intact myotubes, overview Mus musculus (ADP-D-ribosyl)-integrin alpha7 + nicotinamide - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30integrin alpha7 + NAD+ the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin, binding site, overview Mus musculus (ADP-D-ribosyl)-integrin alpha7 + nicotinamide - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more ADP-ribosylation seems to be involved in regulation of differentiation, the enzyme may be centrally involved in tumorigenic cell transformation, the enzyme appears to be a central controller of cell processes: higher activities shift the cell towards proliferation, low activities shift the cell towards differentiation, role of the enzyme in DNA repair Homo sapiens ? - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more cuts produced in vivo on DNA during DNA repair activate the enzyme, which then synthesiszes poly(ADP-ribose) on histone H1, in particular, and contributes to the opening of the 25 nm chromatin fiber, resulting in the increased accessibility of DNA to excision repair enzymes Bos taurus ? - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more the enzyme modifies eukaryotic 21000-24000 Da GTP-binding proteins Clostridium botulinum ? - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more role of the enzyme in DNA repair, the unmodified polymerase molecules bind tightly to DNA strand breaks: auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes Homo sapiens ? - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more mechanistic basis for the physiological function of PARP-1 in the dynamics of the local modulation of chromatin structure. PARP-1 activation upon binding to base-unpaired regions and stem-loops structures in DNA leads to a local PAR modification of histones and non-histone proteins at genomic sites where such DNA structures are formed. Subsequent PARP-1 automodification results in its dissociation from DNA leading to an enzymatic self-inactivation thus ensuring a transient character of chromatin ADP-ribosylation. In combination with the PAR-glycohydrolase degradation of ADP-ribose polymers on acceptor proteins, PARP-1 interaction with DNA secondary structures provides a mechanism for local and transient chromatin modification by PAR during physiological nuclear processes Homo sapiens ? - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more raft association focuses ART2.2 on specific targets that constitutively or inducibly assoiate with lipid rafts Mus musculus ? - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more ART1 is an arginine-specific transferase Mus musculus ? - ?
Show all pathways known for 2.4.2.30Display the word mapDisplay the reaction diagram Show all sequences 2.4.2.30more narE possesses ADP-ribosylating and NAD-glycohydrolase activities Neisseria meningitidis ? - ?
Results 1 - 10 of 192 > >>