EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.4.1.223 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan |
initiation and elongation of heparan sulfate |
Caenorhabditis elegans |
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan |
- |
? |
2.4.1.223 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl |
- |
Caenorhabditis elegans |
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl |
- |
? |
2.4.1.223 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan |
- |
Drosophila melanogaster |
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan |
- |
? |
2.4.1.223 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan |
essential in the heparan sulfate biosynthesis |
Drosophila melanogaster |
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-proteoglycan |
- |
? |
2.4.1.223 | UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl |
- |
Drosophila melanogaster |
UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-benzyloxycarbonyl |
- |
? |
2.4.1.223 | more |
activity is only detectable when enzymes are coexpressed, a mixture of individually expressed enzymes is inactive |
Homo sapiens |
? |
- |
? |
2.4.1.223 | more |
no transfer of N-acetylglucosamine to beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser |
Homo sapiens |
? |
- |
? |
2.4.1.223 | UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser |
46% of the rate with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol |
Homo sapiens |
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser |
- |
? |
2.4.1.223 | UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol |
- |
Homo sapiens |
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl1-O-naphthalenemethanol |
- |
? |
2.4.1.223 | UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-N-acetylgalactosamine |
- |
Homo sapiens |
UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-N-acetylgalactosamine |
- |
? |