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Results 1 - 10 of 10
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EC Number Substrates Commentary Substrates Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.3.2.B1ditrans,ocatacis-undecaprenyl diphosphoryl (GlcNAc-beta-(1->4))MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-Ala-tRNa - ditrans,ocatacis-undecaprenyl diphosphoryl (GlcNAc-beta-(1->4))MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl(N6-L-alanyl)-D-alanyl-D-alanine + tRNA - ?
Display the reaction diagram Show all sequences 2.3.2.B1ditrans,ocatacis-undecaprenyl diphosphoryl MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA i.e. lipid I ? + tRNA - ?
Display the reaction diagram Show all sequences 2.3.2.B1ditrans,ocatacis-undecaprenyl diphosphoryl MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanyl-L-alanyl-gamma-D-glutamyl-L-lysine + alanyl-tRNA - ? + tRNA - ?
Display the reaction diagram Show all sequences 2.3.2.B1more a 30-amino acid long sequence within the MurM protein is the main determinant of the specificity of the reaction, the addition of alanine versus serine ? - ?
Display the reaction diagram Show all sequences 2.3.2.B1more differing stem peptide structures of penicillin-resistant strain 159 and penicillin-susceptible strain Pn16 are caused by the profoundly greater catalytic efficiency of MurM159 compared with MurMPn16 brought about by sequence variation between these enzymes and, to a lesser extent, differences in the in vivo tRNAAla:tRNASer ratio in strains 159 and Pn16. Enzyme MurM additionally recognizes the acceptor stem and/or the TPSIC loop stem of the tRNAAla ? - ?
Display the reaction diagram Show all sequences 2.3.2.B1more MurM acts during the lipid-linked stages of peptidoglycan synthesis.The D-alanyl-D-alanine of the stem peptide and the lipid II N-acetylglucosaminyl group are not essential for substrate recognition. epsilon-Carboxylation of the lysine of the stem peptide is not tolerated. Differing stem peptide structures of penicillin-resistant strain 159 and penicillin-susceptible strain Pn16 are caused by the profoundly greater catalytic efficiency of MurM159 compared with MurMPn16 brought about by sequence variation between these enzymes and, to a lesser extent, differences in the in vivo tRNAAla:tRNASer ratio in strains 159 and Pn16. Enzyme MurM additionally recognizes the acceptor stem and/or the TPSIC loop stem of the tRNAAla ? - ?
Display the reaction diagram Show all sequences 2.3.2.B1UDP-MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA MurMPn16 of penicillin-susceptible strain Pn16 supports serylation more than alanylation both in vivo and in vitro UDP-MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl(N6-L-alanyl)-D-alanyl-D-alanine + tRNA - ?
Display the reaction diagram Show all sequences 2.3.2.B1UDP-MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA in vivo and in vitro, in the presence of the appropriate acyl-tRNA, MurM alanylates the peptidoglycan-amino group of the stem peptide lysine in preference to its serylation UDP-MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl(N6-L-alanyl)-D-alanyl-D-alanine + tRNA - ?
Display the reaction diagram Show all sequences 2.3.2.B1UDP-MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-seryl-tRNA MurMPn16 of penicillin-susceptible strain Pn16 supports serylation more than alanylation both in vivo and in vitro UDP-MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl(N6-L-seryl)-D-alanyl-D-alanine + tRNA - ?
Display the reaction diagram Show all sequences 2.3.2.B1UDP-MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-seryl-tRNA in vivo and in vitro, in the presence of the appropriate acyl-tRNA, MurM alanylates the peptidoglycan-amino group of the stem peptide lysine in preference to its serylation UDP-MurNAc-L-alanyl-gamma-D-glutamyl-L-lysyl(N6-L-seryl)-D-alanyl-D-alanine + tRNA - ?
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