EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.B41 | more |
insignificant activity with SKEYFS(N6-succinyl)KQK |
Archaeoglobus fulgidus |
? |
- |
? |
2.3.1.B41 | more |
no activity with KGLGKGGA(N6-succinyl)KRHRKW |
Archaeoglobus fulgidus |
? |
- |
? |
2.3.1.B41 | more |
no or very low activity with QTAR(N6-acetyl)KSTGG, QTAR(N6-propionyl)KSTGG, QTAR(N6-succinyl)KSTGG, QTAR(N6-butyryl)KSTGG, QTAR(N6-crotonyl)KSTGG |
Homo sapiens |
? |
- |
? |
2.3.1.B41 | more |
Sirt6 prefers long chain fatty acyl groups. Low deacetylase activity on histone H3 K9 and histone H3 K56. Selectivity for peptide sequence is not high |
Homo sapiens |
? |
- |
? |
2.3.1.B41 | more |
the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro |
Homo sapiens |
? |
- |
? |
2.3.1.B41 | more |
SIRT6 forms a complex with MutY homolog, apurinic/apyrimidinic-endonuclease 1, and 9-1-1 checkpoint clamp to maintain genomic and telomeric integrity. SIRT6 enhances the activities of MutY homolog, apurinic/apyrimidinic-endonuclease 1. Human MutY homolog and SIRT6 are efficiently recruited to confined oxidative DNA damage within transcriptionally active chromatin, but not in inactive chromatin |
Mus musculus |
? |
- |
? |
2.3.1.B41 | more |
acetylation of nicotinamide phosphoribosyltransferase, i.e. NAMPT, on residue K53 by SIRT6 |
Homo sapiens |
? |
- |
- |
2.3.1.B41 | more |
SIRT6 deacetylates Beclin-1 in HCC cells |
Homo sapiens |
? |
- |
- |
2.3.1.B41 | more |
SIRT6 is a specific deacetylase for H3K9, see EC 2.3.1.286. It also deacetylates H3K56 and H3K18, as well as KAP1, CtIP, PGC-1alpha, TRF2, GCN5, SNF2H, and PKM2 |
Mus musculus |
? |
- |
- |
2.3.1.B41 | more |
SIRT6 is a specific deacetylase for H3K9, see EC 2.3.1.286. It also deacetylates H3K56 and H3K18, as well as KAP1, CtIP, PGC-1alpha, TRF2, GCN5, SNF2H, and PKM2, cf. EC 2.3.1.286 |
Homo sapiens |
? |
- |
- |