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Results 1 - 10 of 74 > >>
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more insignificant activity with SKEYFS(N6-succinyl)KQK Archaeoglobus fulgidus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more no activity with KGLGKGGA(N6-succinyl)KRHRKW Archaeoglobus fulgidus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more no or very low activity with QTAR(N6-acetyl)KSTGG, QTAR(N6-propionyl)KSTGG, QTAR(N6-succinyl)KSTGG, QTAR(N6-butyryl)KSTGG, QTAR(N6-crotonyl)KSTGG Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more Sirt6 prefers long chain fatty acyl groups. Low deacetylase activity on histone H3 K9 and histone H3 K56. Selectivity for peptide sequence is not high Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more SIRT6 forms a complex with MutY homolog, apurinic/apyrimidinic-endonuclease 1, and 9-1-1 checkpoint clamp to maintain genomic and telomeric integrity. SIRT6 enhances the activities of MutY homolog, apurinic/apyrimidinic-endonuclease 1. Human MutY homolog and SIRT6 are efficiently recruited to confined oxidative DNA damage within transcriptionally active chromatin, but not in inactive chromatin Mus musculus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more acetylation of nicotinamide phosphoribosyltransferase, i.e. NAMPT, on residue K53 by SIRT6 Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more SIRT6 deacetylates Beclin-1 in HCC cells Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more SIRT6 is a specific deacetylase for H3K9, see EC 2.3.1.286. It also deacetylates H3K56 and H3K18, as well as KAP1, CtIP, PGC-1alpha, TRF2, GCN5, SNF2H, and PKM2 Mus musculus ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.B41more SIRT6 is a specific deacetylase for H3K9, see EC 2.3.1.286. It also deacetylates H3K56 and H3K18, as well as KAP1, CtIP, PGC-1alpha, TRF2, GCN5, SNF2H, and PKM2, cf. EC 2.3.1.286 Homo sapiens ? - -
Results 1 - 10 of 74 > >>