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Results 1 - 10 of 59 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
more
insignificant activity with SKEYFS(N6-succinyl)KQK
?
-
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no activity with KGLGKGGA(N6-succinyl)KRHRKW
?
-
-
more
no or very low activity with QTAR(N6-acetyl)KSTGG, QTAR(N6-propionyl)KSTGG, QTAR(N6-succinyl)KSTGG, QTAR(N6-butyryl)KSTGG, QTAR(N6-crotonyl)KSTGG
?
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-
more
Sirt6 prefers long chain fatty acyl groups. Low deacetylase activity on histone H3 K9 and histone H3 K56. Selectivity for peptide sequence is not high
?
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-
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the enzyme preferentially hydrolyzes long-chain fatty acyl groups over acetyl groups in vitro
?
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SIRT6 forms a complex with MutY homolog, apurinic/apyrimidinic-endonuclease 1, and 9-1-1 checkpoint clamp to maintain genomic and telomeric integrity. SIRT6 enhances the activities of MutY homolog, apurinic/apyrimidinic-endonuclease 1. Human MutY homolog and SIRT6 are efficiently recruited to confined oxidative DNA damage within transcriptionally active chromatin, but not in inactive chromatin
?
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-
NAD+ + Ac-AK(N6-acetyl)K-7-amido-4-methylcoumarin
the substrate is based on the human tumour suppressor protein p53
nicotinamide + Ac-AKK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose
-
?
NAD+ + Ac-HK(N6-acetyl)K-7-amido-4-methylcoumarin
the substrate is based on the human tumour suppressor protein p53
nicotinamide + Ac-HKK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose
-
?
NAD+ + Ac-RHK(N6-acetyl)K-7-amido-4-methylcoumarin
the substrate is based on the amino acids 379-382 of the human tumour suppressor protein p53
nicotinamide + Ac-RHKK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose
-
?
NAD+ + Ac-RYQ(N6-acetyl)K-7-amido-4-methylcoumarin
the peptide substrate mimics the biological deacetylation site of histone H3 K56
nicotinamide + Ac-RYQK-7-amido-4-methylcoumarin + 2'-O-acetyl-ADP-ribose
-
?
Results 1 - 10 of 59 > >>