EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.160 | 11-methoxy-16-epivellosimine + acetyl-CoA |
- |
Rauvolfia serpentina |
CoA + 11-methoxy-vinorine |
- |
? |
2.3.1.160 | 16-epi-vellosimine + acetyl-CoA |
VS responsible for generation of the basic carbon skeleton of the target compound ajmaline, His160 and Asp164 are the most important amino acids for the catalytic process, His-X-X-X-Asp sequence together with Asp-Phe-Gly-Trp-Gly are highly conserved motifs in acyltransferases |
Rauvolfia serpentina |
vinorine + CoA |
- |
? |
2.3.1.160 | acetyl-CoA + 16-epivellosimine |
- |
Rauvolfia serpentina |
CoA + vinorine |
- |
? |
2.3.1.160 | acetyl-CoA + 16-epivellosimine |
the enzyme is involved in a crucial step of antiarrhythmic drug ajmaline biosynthesis, pathway overview |
Rauvolfia serpentina x Rhazya stricta |
CoA + vinorine |
- |
? |
2.3.1.160 | more |
no activity with polyneuridine, vomilenine, 17-O-acetyl-norajmaline, and N-methylgardneral |
Rauvolfia serpentina x Rhazya stricta |
? |
- |
? |
2.3.1.160 | more |
the acetylation is important for stabilization of the immediate indolenine 17-deacetyl-vinorine, which would otherwise be spontaneously re-transformed |
Rauvolfia serpentina x Rhazya stricta |
? |
- |
? |
2.3.1.160 | acetyl-CoA + 16-epivellosimine |
- |
Rauvolfia serpentina |
CoA + vinorine |
- |
r |
2.3.1.160 | acetyl-CoA + 16-epivellosimine |
the enzyme is involved in a crucial step of antiarrhythmic drug ajmaline biosynthesis, pathway overview |
Rauvolfia serpentina x Rhazya stricta |
CoA + vinorine |
- |
r |
2.3.1.160 | acetyl-CoA + 16-epivellosimine |
the enzyme is involved in a crucial step of antiarrhythmic drug ajmaline biosynthesis, pathway overview |
Rauvolfia serpentina |
CoA + vinorine |
- |
r |
2.3.1.160 | acetyl-CoA + 16-epivellosimine |
substrate specificity in both reaction directions, the reverse reaction is preferred |
Rauvolfia serpentina x Rhazya stricta |
CoA + vinorine |
- |
r |