EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.256 | S-adenosyl-L-methionine + guanine6 in tRNACys |
Trm14 generates m2G at position 6 in tRNACys |
Methanocaldococcus jannaschii |
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys |
- |
? |
2.1.1.256 | S-adenosyl-L-methionine + guanine6 in tRNACys |
wild-type or G6A/C67U tRNACys transcripts as substrates, Trm14 generates m2G at position 6 in tRNACys, i.e. tRNACys m2G6-forming activity |
Methanocaldococcus jannaschii |
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys |
- |
? |
2.1.1.256 | S-adenosyl-L-methionine + guanine6 in tRNACys |
Trm14 generates m2G at position 6 in tRNACys |
Methanocaldococcus jannaschii JAL-1 |
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys |
- |
? |
2.1.1.256 | S-adenosyl-L-methionine + guanine6 in tRNACys |
wild-type or G6A/C67U tRNACys transcripts as substrates, Trm14 generates m2G at position 6 in tRNACys, i.e. tRNACys m2G6-forming activity |
Methanocaldococcus jannaschii JAL-1 |
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys |
- |
? |
2.1.1.256 | more |
active site structure with bound ligands, S-adenosyl-L-methionine, S-adenosyl-L-homocysteine, and sinefungin, overview |
Pyrococcus furiosus |
? |
- |
? |
2.1.1.256 | S-adenosyl-L-methionine + guanine6 in tRNA |
the enzyme specifically modifies tRNAPhe at guanosine 6 in the tRNA acceptor stem |
Pyrococcus furiosus |
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA |
- |
? |
2.1.1.256 | S-adenosyl-L-methionine + guanine6 in tRNA |
the enzyme specifically modifies tRNAPhe at guanosine 6 in the tRNA acceptor stem. Contribution of the THUMP domain in tRNA recognition and catalysis, substrate binding and ligand-induced conformational changes in the RFM domain |
Pyrococcus furiosus |
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA |
- |
? |
2.1.1.256 | S-adenosyl-L-methionine + guanine6 in tRNA(Phe) |
production of a small amount of N2-dimethylguanine6 in tRNA(Phe) |
Pyrococcus furiosus |
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA(Phe) |
- |
? |
2.1.1.256 | S-adenosyl-L-methionine + guanine37 in tRNATrp |
- |
Thermococcus kodakarensis |
S-adenosyl-L-homocysteine + N2-methylguanine37 in tRNATrp |
- |
? |
2.1.1.256 | S-adenosyl-L-methionine + guanine54 in tRNATrp |
- |
Thermococcus kodakarensis |
S-adenosyl-L-homocysteine + N2-methylguanine54 in tRNATrp |
- |
? |