EC Number   |
Substrates |
Products |
Reversibility |
|---|
  2.1.1.225 | more |
Trm13p belongs to the RFM superfamily of MTases despite the absence of a significant sequence similarity to previously characterized members of this superfamily. The model reveals residues potentially responsible for cofactor binding, tRNA binding, and catalysis of the 2'-O-methylation reaction. The model suggests a presence of one to three disulfide bonds and/or metal ion binding site next to the substrate binding pocket |
? |
- |
? |
| 2.1.1.225 | S-adenosyl-L-methionine + adenosine4 in tRNAHis |
the enzyme is necessary and sufficient for 2'-O-methylation at position 4 of yeast tRNA. 2'-O-methylation in the acceptor stem of tRNA |
S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis |
- |
? |
| 2.1.1.225 | S-adenosyl-L-methionine + adenosine4 in tRNAHis |
- |
S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis |
- |
? |
| 2.1.1.225 | S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC) |
the enzyme is necessary and sufficient for 2'-O-methylation at position 4 of yeast tRNA. 2'-O-methylation in the acceptor stem of tRNA |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC) |
- |
? |
| 2.1.1.225 | S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC) |
- |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC) |
- |
? |
| 2.1.1.225 | S-adenosyl-L-methionine + cytidine4 in tRNAPro |
the enzyme is necessary and sufficient for 2'-O-methylation at position 4 of yeast tRNA. 2'-O-methylation in the acceptor stem of tRNA |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro |
- |
? |
| 2.1.1.225 | S-adenosyl-L-methionine + cytidine4 in tRNAPro |
- |
S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro |
- |
? |
