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Results 1 - 10 of 13 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
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the bifunctional methyltransferase YcbY, i.e. RlmKL, adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA, recognition of dual rRNA targets by YcbY
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helix 80 and the 12 nt ss region are critical sites necessary for m2G2445 and m7G2069 formation. Transcript 7, which lacks helix 80 and the 12 nt single-strand region, is not methylated at either position
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Smu776 does not target G2069, and this nucleotide remains unmodified in Gram-positive rRNAs
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S-adenosyl-L-methionine + guanine2069 in 23S rRNA
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S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA
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S-adenosyl-L-methionine + guanine2069 in 23S rRNA
m7G2069 modification by YcbY is stoichiometric
S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA
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S-adenosyl-L-methionine + guanine2445 in 23S rRNA
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S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA
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S-adenosyl-L-methionine + guanine2445 in 23S rRNA
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S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA
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S-adenosyl-L-methionine + guanine2445 in 23S rRNA
N2-methylguanosine2445 of the 23S rRNA is located in a cluster of modified nucleotides concentrated at the peptidyl transferase center of the ribosome. It is likely that the G2445 modification is necessary for prevention of nonfunctional secondary or tertiary structure formation at the peptidyl transferase center
S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA
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S-adenosyl-L-methionine + guanine2445 in 23S rRNA
recombinant YcbY protein is able to methylate 23S rRNA purified from the ycbY knock-out strain in vitro, assembled 50S subunits are not a substrate for the methylase
S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA
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S-adenosyl-L-methionine + guanine2445 in 23S rRNA
RlmL possessing an additional RNA-binding domain acts on naked ribosomal RNA or early assembly intermediates in the cell
S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA
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Results 1 - 10 of 13 > >>