EC Number   |
Substrates |
Products |
Reversibility |
|---|
   1.21.1.1 | 2-iodophenol + NADP+ + iodide |
2-iodophenol binds very weakly to the enzyme and is dehalogenated with a catalytic efficiency that is more than 4 orders of magnitude lower than that for 3-iodo-L-tyrosine |
? |
- |
? |
| 1.21.1.1 | 3,5-diiodo-L-tyrosine + dithionite |
- |
3-iodo-L-tyrosine + ? + I- |
- |
? |
| 1.21.1.1 | 3,5-diiodo-L-tyrosine + dithionite |
solubilized enzyme preparations are active with dithionite, but not with NADPH. Particle-bound enzyme uses both dithionite and NADPH. At concentrations of substrate below 1 microM, 3,5-diiodo-L-tyrosine is more rapidly deiodinated than 3-iodo-L-tyrosine, which is reversed at concentrations greater than 5 microM |
3-iodo-L-tyrosine + ? + I- |
- |
? |
| 1.21.1.1 | 3,5-diiodo-L-tyrosine + NADPH + H+ |
- |
3-iodo-L-tyrosine + NADP+ + I- |
- |
? |
| 1.21.1.1 | 3,5-diiodo-L-tyrosine + NADPH + H+ |
solubilized enzyme preparations are active with dithionite, but not with NADPH. Particle-bound enzyme uses both dithionite and NADPH. At concentrations of substrate below 1 microM, 3,5-diiodo-L-tyrosine is more rapidly deiodinated than 3-iodo-L-tyrosine, which is reversed at concentrations greater than 5 microM |
3-iodo-L-tyrosine + NADP+ + I- |
- |
? |
| 1.21.1.1 | 3,5-diiodo-L-tyrosine + NADPH + H+ |
substrate 3-iodo-L-tyrosine is preferred over 3,5-diiodotyrosine |
3-iodo-L-tyrosine + NADP+ + I- |
- |
? |
| 1.21.1.1 | 3-bromo-L-tyrosine + NADP+ + bromide |
- |
3,5-dibromo-L-tyrosine + NADPH + H+ |
- |
? |
| 1.21.1.1 | 3-bromo-L-tyrosine + NADPH + H+ |
- |
L-tyrosine + NADP+ + Br- |
- |
? |
| 1.21.1.1 | 3-chloro-L-tyrosine + NADP+ + chloride |
- |
3,5-dichloro-L-tyrosine + NADPH + H+ |
- |
? |
| 1.21.1.1 | 3-chloro-L-tyrosine + NADP+ + chloride |
low activity |
3,5-dichloro-L-tyrosine + NADPH + H+ |
- |
? |
