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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.5311-deoxycortisol + NADH + H+ i.e. 4-pregnen-17,21-diol-3,20-dione, 49.8% of the activity compared to cortisone Agathobaculum desmolans ? + NAD+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.5320beta-hydroxycortisone + NADH + H+ under in vitro conditions, the enzyme catalyzes reductive reaction far more readily than oxidative reaction Agathobaculum desmolans cortisone + NADH + H+ - r
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.53corticosterone + NADH + H+ i.e. 4-pregnen-11beta,21-diol-3,20-dione, 39.8% of the activity compared to cortisone Agathobaculum desmolans ? + NAD+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.53cortisone + NADH + H+ the equilibrium for the recombinant enzyme clearly favors the reductive direction. Cortisol is the preferred substrate, as it is more rapidly converted to 20beta-dihydrocortisol relative to other structurally similar steroids tested Agathobaculum desmolans 20beta-hydroxycortisone + NAD+ - r
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.53tetrahydrocortisol + NADH + H+ i.e. 5beta-pregnan-3alpha,11beta,17,21-tetrol-20-one, 49.2% of the activity compared to cortisone Agathobaculum desmolans ? + NAD+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.5311-deoxycortisol + NADH + H+ i.e. 4-pregnen-17,21-diol-3,20-dione, 49.8% of the activity compared to cortisone Agathobaculum desmolans ATCC 43058 ? + NAD+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.5320beta-hydroxycortisone + NADH + H+ under in vitro conditions, the enzyme catalyzes reductive reaction far more readily than oxidative reaction Agathobaculum desmolans ATCC 43058 cortisone + NADH + H+ - r
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.53corticosterone + NADH + H+ i.e. 4-pregnen-11beta,21-diol-3,20-dione, 39.8% of the activity compared to cortisone Agathobaculum desmolans ATCC 43058 ? + NAD+ - ?
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.53cortisone + NADH + H+ the equilibrium for the recombinant enzyme clearly favors the reductive direction. Cortisol is the preferred substrate, as it is more rapidly converted to 20beta-dihydrocortisol relative to other structurally similar steroids tested Agathobaculum desmolans ATCC 43058 20beta-hydroxycortisone + NAD+ - r
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.53tetrahydrocortisol + NADH + H+ i.e. 5beta-pregnan-3alpha,11beta,17,21-tetrol-20-one, 49.2% of the activity compared to cortisone Agathobaculum desmolans ATCC 43058 ? + NAD+ - ?
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