EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.320 | more |
the enzyme is preferentiallly active on aromatic 1,2-diketones. It catalyzes the stereoselective monoreduction and desymmerization of bulky dicarbonyls. Mechanism and in silico prediction of substrates reactivity, overview |
Ogataea glucozyma |
? |
- |
- |
1.1.1.320 | 1-(2-fluorophenyl)ethanone + NADPH + H+ |
76% of the rate with 1-(4-nitrophenyl)ethanone, 97% yield, 94% enantiomeric excess |
Ogataea glucozyma |
(1S)-1-(2-fluorophenyl)ethanol + NADP+ |
- |
? |
1.1.1.320 | 1-(2-nitrophenyl)ethanone + NADPH + H+ |
53% of the rate with 1-(4-nitrophenyl)ethanone, 78% yield, 98% enantiomeric excess |
Ogataea glucozyma |
(1S)-1-(2-nitrophenyl)ethanol + NADP+ |
- |
? |
1.1.1.320 | 1-(3-fluorophenyl)ethanone + NADPH + H+ |
61% of the rate with 1-(4-nitrophenyl)ethanone, 85% yield, 98% enantiomeric excess |
Ogataea glucozyma |
(1S)-1-(3-fluorophenyl)ethanol + NADP+ |
- |
? |
1.1.1.320 | 1-(4-fluoro-phenyl)-2-phenyl-ethane-1,2-dione + NADPH + H+ |
- |
Bacillus cereus |
? + NADP+ |
- |
? |
1.1.1.320 | 1-(4-methyl-phenyl)-2-phenyl-ethane-1,2-dione + NADPH + H+ |
- |
Bacillus cereus |
? + NADP+ |
- |
? |
1.1.1.320 | 1-(4-nitrophenyl)ethanone + NADPH + H+ |
100% yield, 98% enantiomeric excess |
Ogataea glucozyma |
(1S)-1-(4-nitrophenyl)ethanol + NADP+ |
- |
? |
1.1.1.320 | 1-(furan-2-yl)ethanone + NADPH + H+ |
- |
Ogataea glucozyma |
(1S)-1-(furan-2-yl)ethanol + NADP+ |
48% of the activity with benzil, 95% yield, 98% enantiomeric excess |
? |
1.1.1.320 | 1-(pyridin-3-yl)ethanone + NADPH + H+ |
- |
Ogataea glucozyma |
(S)-(1-pyridin-3yl)ethanol + NADP+ |
58% of the activity with benzil, 95% yield, 98% enantiomeric excess |
? |
1.1.1.320 | 1-(pyridin-3-yl)propan-1-one + NADPH + H+ |
- |
Ogataea glucozyma |
(S)-1-(pyridin-3-yl)propanol + NADP+ |
60% of the activity with benzil, 95% yield, 98% enantiomeric excess |
? |